STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiDAcetyltransferase; TPP riboswitch; Derived by automated computational analysis using gene prediction method: cmsearch. (266 aa)    
Predicted Functional Partners:
thiE
Thiamine-phosphate diphosphorylase; Catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.998
thiC
Phosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
 
 0.985
AOW47248.1
Thiamine phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.965
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.802
AOW45989.1
Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.766
AOW45580.1
Adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.666
guaB
IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.516
rhlE
DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.
 
 
   0.508
truA
tRNA pseudouridine(38,39,40) synthase TruA; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
  
    0.485
guaA
Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
   
 0.451
Your Current Organism:
Acetobacter ascendens
NCBI taxonomy Id: 481146
Other names: A. ascendens, Acetobacter pasteurianus subsp. ascendens, Acetobacter pasteurianus subsp. paradoxus, Bacterium ascendans, CCUG 18128, LMD 51.1, LMD 53.6 [[Acetobacter pasteurianus subsp. paradoxus]], NCCB 51001, NCCB 53006 [[Acetobacter pasteurianus subsp. paradoxus]]
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