glcU_1 protein (Lactobacillus sunkii) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

glcU_1

Glucose uptake protein GlcU. (284 aa)

Predicted Functional Partners:

OFA11112.1

0.475

OFA11281.1

0.455

fliY

0.423

pstS1_1

0.421

OFA11280.1

0.419

OFA10080.1

0.413

OFA11043.1

0.410

OFA09435.1

0.403

Your Current Organism:

Lactobacillus sunkii

NCBI taxonomy Id: 481719
Other names: DSM 19904, JCM 15039, L. sunkii, Lactobacillus sp. YIT 11161, Lactobacillus sp. YIT 11442, Lactobacillus sp. YIT 11539, Lactobacillus sp. YIT 11549, Lactobacillus sp. YIT 11557, Lactobacillus sp. YIT 11635, Lactobacillus sunkii Watanabe et al. 2009, NRIC 0744, YIT 11161

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OFA09435.1	glcU_1	LASUN_25260	LASUN_08910	Sortase family protein.	Glucose uptake protein GlcU.	0.403
OFA10080.1	glcU_1	LASUN_20190	LASUN_08910	GDSL-like lipase/acylhydrolase.	Glucose uptake protein GlcU.	0.413
OFA11043.1	glcU_1	LASUN_11120	LASUN_08910	Nitroreductase family protein.	Glucose uptake protein GlcU.	0.410
OFA11112.1	glcU_1	LASUN_11840	LASUN_08910	Glycerophosphoryl diester phosphodiesterase family protein.	Glucose uptake protein GlcU.	0.475
OFA11280.1	OFA11281.1	LASUN_08890	LASUN_08900	Hypothetical protein.	Hypothetical protein.	0.501
OFA11280.1	glcU_1	LASUN_08890	LASUN_08910	Hypothetical protein.	Glucose uptake protein GlcU.	0.419
OFA11281.1	OFA11280.1	LASUN_08900	LASUN_08890	Hypothetical protein.	Hypothetical protein.	0.501
OFA11281.1	glcU_1	LASUN_08900	LASUN_08910	Hypothetical protein.	Glucose uptake protein GlcU.	0.455
fliY	glcU_1	LASUN_12050	LASUN_08910	Cystine-binding periplasmic protein precursor.	Glucose uptake protein GlcU.	0.423
fliY	pstS1_1	LASUN_12050	LASUN_03120	Cystine-binding periplasmic protein precursor.	Phosphate-binding protein PstS 1 precursor.	0.406
glcU_1	OFA09435.1	LASUN_08910	LASUN_25260	Glucose uptake protein GlcU.	Sortase family protein.	0.403
glcU_1	OFA10080.1	LASUN_08910	LASUN_20190	Glucose uptake protein GlcU.	GDSL-like lipase/acylhydrolase.	0.413
glcU_1	OFA11043.1	LASUN_08910	LASUN_11120	Glucose uptake protein GlcU.	Nitroreductase family protein.	0.410
glcU_1	OFA11112.1	LASUN_08910	LASUN_11840	Glucose uptake protein GlcU.	Glycerophosphoryl diester phosphodiesterase family protein.	0.475
glcU_1	OFA11280.1	LASUN_08910	LASUN_08890	Glucose uptake protein GlcU.	Hypothetical protein.	0.419
glcU_1	OFA11281.1	LASUN_08910	LASUN_08900	Glucose uptake protein GlcU.	Hypothetical protein.	0.455
glcU_1	fliY	LASUN_08910	LASUN_12050	Glucose uptake protein GlcU.	Cystine-binding periplasmic protein precursor.	0.423
glcU_1	pstS1_1	LASUN_08910	LASUN_03120	Glucose uptake protein GlcU.	Phosphate-binding protein PstS 1 precursor.	0.421
pstS1_1	fliY	LASUN_03120	LASUN_12050	Phosphate-binding protein PstS 1 precursor.	Cystine-binding periplasmic protein precursor.	0.406
pstS1_1	glcU_1	LASUN_03120	LASUN_08910	Phosphate-binding protein PstS 1 precursor.	Glucose uptake protein GlcU.	0.421

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.807

expected number of edges:

12

PPI enrichment p-value:

3.08e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003724

RNA helicase activity

4 of 4

2.49

2.93

2.82e-06

GO:0016818

Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

6 of 86

1.33

1.49

3.11e-05

GO:0052857

NADPHX epimerase activity

2 of 2

2.49

1.35

0.0033

GO:0052856

NADHX epimerase activity

2 of 2

2.49

1.35

0.0033

GO:0016462

Pyrophosphatase activity

5 of 83

1.27

1.17

0.00048

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1173

0.46

0.38

0.0010

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1694

NADHX epimerase activity, and RNA helicase activity

6 of 6

2.49

5.11

7.34e-11

CL:1692

Mixed, incl. RNA helicase activity, and NADHX epimerase activity

7 of 14

2.19

4.82

2.69e-11

CL:1396

Mixed, incl. Translation, and ATP-dependent activity

9 of 194

1.16

1.5

9.80e-08

CL:1397

Mixed, incl. Translation, and Ribonucleoside triphosphate biosynthetic process

8 of 164

1.18

1.46

9.72e-07

CL:2444

tRNA threonylcarbamoyladenosine modification, and dephospho-CoA kinase activity

2 of 6

2.01

0.75

0.0398

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

5 of 27

1.76

2.36

2.71e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043590

Bacterial nucleoid

4 of 10

2.09

2.39

1.50e-05

GOCC:0005622

Intracellular

10 of 1239

0.4

0.29

0.0268

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0347

Helicase

4 of 26

1.68

1.57

0.00033

KW-0346

Stress response

2 of 10

1.79

0.77

0.0332

KW-0067

ATP-binding

6 of 277

0.83

0.56

0.0108

KW-0963

Cytoplasm

5 of 274

0.75

0.42

0.0466

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011545

DEAD/DEAH box helicase domain

4 of 9

2.14

6.17e-05

IPR014014

RNA helicase, DEAD-box type, Q motif

3 of 3

2.49

1.89

0.00031

IPR001650

Helicase, C-terminal

4 of 18

1.84

1.68

0.00031

IPR014001

Helicase superfamily 1/2, ATP-binding domain

4 of 20

1.79

1.65

0.00031

IPR000629

ATP-dependent RNA helicase DEAD-box, conserved site

2 of 2

2.49

0.97

0.0169

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00490

Helicase superfamily c-terminal domain

4 of 17

1.86

2.03

4.37e-05

SM00487

DEAD-like helicases superfamily

4 of 17

1.86

2.03

4.37e-05

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