OFA11174.1 protein (Lactobacillus sunkii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

OFA11174.1

Hypothetical protein. (150 aa)

Predicted Functional Partners:

OFA11172.1

0.983

OFA11173.1

0.982

xpsE

0.972

OFA09572.1

0.885

OFA09809.1

0.745

uvrB_3

0.738

comC

0.726

OFA13178.1

0.704

OFA09871.1

0.664

OFA09765.1

0.650

Your Current Organism:

Lactobacillus sunkii

NCBI taxonomy Id: 481719
Other names: DSM 19904, JCM 15039, L. sunkii, Lactobacillus sp. YIT 11161, Lactobacillus sp. YIT 11442, Lactobacillus sp. YIT 11539, Lactobacillus sp. YIT 11549, Lactobacillus sp. YIT 11557, Lactobacillus sp. YIT 11635, Lactobacillus sunkii Watanabe et al. 2009, NRIC 0744, YIT 11161

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OFA09572.1	OFA11172.1	LASUN_24750	LASUN_12440	ComEC family competence protein.	Type IV pilin biogenesis protein.	0.943
OFA09572.1	OFA11173.1	LASUN_24750	LASUN_12450	ComEC family competence protein.	Hypothetical protein.	0.882
OFA09572.1	OFA11174.1	LASUN_24750	LASUN_12460	ComEC family competence protein.	Hypothetical protein.	0.885
OFA09572.1	comC	LASUN_24750	LASUN_21270	ComEC family competence protein.	Type 4 prepilin-like protein leader peptide-processing enzyme.	0.892
OFA09572.1	uvrB_3	LASUN_24750	LASUN_14660	ComEC family competence protein.	UvrABC system protein B.	0.844
OFA09572.1	xpsE	LASUN_24750	LASUN_12430	ComEC family competence protein.	Type II secretion system protein E.	0.901
OFA09765.1	OFA11174.1	LASUN_22470	LASUN_12460	RNA polymerase factor sigma-70.	Hypothetical protein.	0.650
OFA09765.1	OFA13178.1	LASUN_22470	LASUN_01770	RNA polymerase factor sigma-70.	Hypothetical protein.	0.478
OFA09809.1	OFA09871.1	LASUN_22910	LASUN_23530	Hypothetical protein.	CAAX amino terminal protease self- immunity.	0.412
OFA09809.1	OFA11174.1	LASUN_22910	LASUN_12460	Hypothetical protein.	Hypothetical protein.	0.745
OFA09871.1	OFA09809.1	LASUN_23530	LASUN_22910	CAAX amino terminal protease self- immunity.	Hypothetical protein.	0.412
OFA09871.1	OFA11174.1	LASUN_23530	LASUN_12460	CAAX amino terminal protease self- immunity.	Hypothetical protein.	0.664
OFA09871.1	OFA13178.1	LASUN_23530	LASUN_01770	CAAX amino terminal protease self- immunity.	Hypothetical protein.	0.656
OFA11172.1	OFA09572.1	LASUN_12440	LASUN_24750	Type IV pilin biogenesis protein.	ComEC family competence protein.	0.943
OFA11172.1	OFA11173.1	LASUN_12440	LASUN_12450	Type IV pilin biogenesis protein.	Hypothetical protein.	0.983
OFA11172.1	OFA11174.1	LASUN_12440	LASUN_12460	Type IV pilin biogenesis protein.	Hypothetical protein.	0.983
OFA11172.1	comC	LASUN_12440	LASUN_21270	Type IV pilin biogenesis protein.	Type 4 prepilin-like protein leader peptide-processing enzyme.	0.892
OFA11172.1	uvrB_3	LASUN_12440	LASUN_14660	Type IV pilin biogenesis protein.	UvrABC system protein B.	0.685
OFA11172.1	xpsE	LASUN_12440	LASUN_12430	Type IV pilin biogenesis protein.	Type II secretion system protein E.	0.997
OFA11173.1	OFA09572.1	LASUN_12450	LASUN_24750	Hypothetical protein.	ComEC family competence protein.	0.882

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.788

expected number of edges:

18

PPI enrichment p-value:

3.54e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007186

G protein-coupled receptor signaling pathway

11 of 692

1.68

4.1

2.54e-15

GO:0007212

Dopamine receptor signaling pathway

4 of 29

2.62

3.4

4.04e-07

GO:0007191

Adenylate cyclase-activating dopamine receptor signaling pathway

3 of 7

3.12

3.0

3.56e-06

GO:0031279

Regulation of cyclase activity

3 of 33

2.44

2.15

9.22e-05

GO:0007606

Sensory perception of chemical stimulus

3 of 38

2.38

2.06

0.00013

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031681

G-protein beta-subunit binding

3 of 13

2.85

2.41

3.97e-05

GO:0031683

G-protein beta/gamma-subunit complex binding

3 of 25

2.56

2.11

0.00012

GO:0030159

Signaling receptor complex adaptor activity

3 of 43

2.33

1.83

0.00036

GO:0044877

Protein-containing complex binding

6 of 1080

1.23

1.15

0.00036

GO:0001664

G protein-coupled receptor binding

3 of 161

1.75

1.04

0.0083

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

9 of 33

2.92

11.15

2.10e-22

GO:0005886

Plasma membrane

11 of 4843

0.84

0.91

6.11e-08

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:36820

Transducer, and G beta:gamma signalling through PLC beta

10 of 137

2.35

8.28

1.05e-19

CL:36832

GTPase complex, and Prostanoid receptor

7 of 33

2.81

7.87

6.44e-16

CL:36821

Mixed, incl. Amine ligand-binding receptors, and GTPase complex

9 of 121

2.36

7.61

1.01e-17

CL:36824

Mixed, incl. GTPase complex, and Amine ligand-binding receptors

8 of 103

2.37

6.86

1.51e-15

CL:36833

GTPase complex, and GPCR, family 2, latrophilin

4 of 24

2.71

3.88

5.28e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04371

Apelin signaling pathway

7 of 174

2.09

4.78

7.85e-12

map04020

Calcium signaling pathway

3 of 350

1.42

0.8

0.0182

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8964315

G beta:gamma signalling through BTK

7 of 12

3.25

9.49

2.83e-18

MAP-8964616

G beta:gamma signalling through CDC42

7 of 13

3.21

9.46

2.83e-18

MAP-500657

Presynaptic function of Kainate receptors

7 of 17

3.1

9.18

6.48e-18

MAP-418217

G beta:gamma signalling through PLC beta

7 of 17

3.1

9.18

6.48e-18

MAP-392170

ADP signalling through P2Y purinoceptor 12

7 of 17

3.1

9.18

6.48e-18

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

10 of 12472

0.39

0.32

0.0034

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 9

3.13

4.46

6.96e-09

GOCC:0005886

Plasma membrane

8 of 2309

1.02

1.08

1.37e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

4 of 261

1.67

1.54

0.00038

KW-0807

Transducer

4 of 315

1.59

1.48

0.00039

KW-0677

Repeat

4 of 866

1.15

0.73

0.0133

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016346

Guanine nucleotide-binding protein, beta subunit

4 of 4

3.48

4.7

3.16e-09

IPR001632

G-protein, beta subunit

4 of 5

3.39

4.69

3.16e-09

IPR001770

G-protein, gamma subunit

3 of 8

3.06

2.74

1.04e-05

IPR036284

G-protein gamma-like domain superfamily

3 of 12

2.88

2.59

1.86e-05

IPR015898

G-protein gamma-like domain

3 of 12

2.88

2.59

1.86e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00224

G protein gamma subunit-like motifs

2 of 11

2.74

1.39

0.0030

SM00320

WD40 repeats

4 of 283

1.63

1.32

0.0013

SM00275

G protein alpha subunit

2 of 19

2.51

1.24

0.0053

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About