STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (228 aa)    
Predicted Functional Partners:
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
  
 0.973
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
 
 0.917
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
  
 0.839
EIQ81054.1
Para-aminobenzoate synthetase component I/4-amino-4-deoxychorismate lyase; COG0147 Anthranilate/para-aminobenzoate synthases component I.
 
  
 0.827
EIQ81729.1
Hypothetical protein; COG1092 Predicted SAM-dependent methyltransferases.
       0.798
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
   
 0.786
EIQ82826.1
Hypothetical protein; COG0021 Transketolase.
 
  
 0.782
EIQ81591.1
Hypothetical protein; COG1605 Chorismate mutase.
 
  
 0.626
EIQ82364.1
Hypothetical protein; COG3265 Gluconate kinase.
    
 0.591
EIQ81728.1
Sulfatase family protein; COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily.
       0.577
Your Current Organism:
Streptococcus canis
NCBI taxonomy Id: 482234
Other names: S. canis FSL Z3-227, Streptococcus canis FSL Z3-227, Streptococcus canis str. FSL Z3-227, Streptococcus canis strain FSL Z3-227
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.