node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EIQ82702.1 | EIQ83004.1 | SCAZ3_10085 | SCAZ3_00075 | Pur operon repressor; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.782 |
EIQ82702.1 | apt | SCAZ3_10085 | SCAZ3_07175 | Pur operon repressor; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.732 |
EIQ82702.1 | gmk | SCAZ3_10085 | SCAZ3_08845 | Pur operon repressor; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.833 |
EIQ82702.1 | guaA | SCAZ3_10085 | SCAZ3_06245 | Pur operon repressor; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.974 |
EIQ82702.1 | guaB | SCAZ3_10085 | SCAZ3_11485 | Pur operon repressor; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.907 |
EIQ82702.1 | guaC | SCAZ3_10085 | SCAZ3_06420 | Pur operon repressor; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. | Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.771 |
EIQ82702.1 | purA | SCAZ3_10085 | SCAZ3_01175 | Pur operon repressor; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.691 |
EIQ82702.1 | purH | SCAZ3_10085 | SCAZ3_00435 | Pur operon repressor; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.844 |
EIQ82702.1 | xpt | SCAZ3_10085 | SCAZ3_06415 | Pur operon repressor; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.783 |
EIQ83004.1 | EIQ82702.1 | SCAZ3_00075 | SCAZ3_10085 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Pur operon repressor; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. | 0.782 |
EIQ83004.1 | apt | SCAZ3_00075 | SCAZ3_07175 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.810 |
EIQ83004.1 | gmk | SCAZ3_00075 | SCAZ3_08845 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.775 |
EIQ83004.1 | guaA | SCAZ3_00075 | SCAZ3_06245 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.940 |
EIQ83004.1 | guaB | SCAZ3_00075 | SCAZ3_11485 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.928 |
EIQ83004.1 | guaC | SCAZ3_00075 | SCAZ3_06420 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.766 |
EIQ83004.1 | purA | SCAZ3_00075 | SCAZ3_01175 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.816 |
EIQ83004.1 | purH | SCAZ3_00075 | SCAZ3_00435 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.798 |
EIQ83004.1 | pyrD | SCAZ3_00075 | SCAZ3_07910 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Dihydroorotate dehydrogenase 1A; Catalyzes the conversion of dihydroorotate to orotate. | 0.759 |
EIQ83004.1 | xpt | SCAZ3_00075 | SCAZ3_06415 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.829 |
apt | EIQ82702.1 | SCAZ3_07175 | SCAZ3_10085 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Pur operon repressor; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. | 0.732 |