OPX43577.1 protein (Ruminiclostridium hungatei)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

OPX43577.1

Putative glycosyl transferase. (406 aa)

Predicted Functional Partners:

fcl_1

0.976

wbpI_2

0.918

glgB

0.870

capD_2

0.841

mshA

0.769

gmhB

0.758

hddC_2

0.755

hddC_1

0.752

OPX43581.1

0.686

OPX46029.1

0.630

Your Current Organism:

Ruminiclostridium hungatei

NCBI taxonomy Id: 48256
Other names: ATCC 700212, Clostridium hungatei, Clostridium hungatei Monserrate et al. 2001, DSM 14427, R. hungatei, strain AD

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OPX43577.1	OPX43581.1	CLHUN_25150	CLHUN_25190	Putative glycosyl transferase.	Hypothetical protein.	0.686
OPX43577.1	OPX46029.1	CLHUN_25150	CLHUN_05040	Putative glycosyl transferase.	Alpha/beta hydrolase family protein.	0.630
OPX43577.1	capD_2	CLHUN_25150	CLHUN_25180	Putative glycosyl transferase.	UDP-glucose 4-epimerase.	0.841
OPX43577.1	fcl_1	CLHUN_25150	CLHUN_25170	Putative glycosyl transferase.	GDP-L-fucose synthase.	0.976
OPX43577.1	glgB	CLHUN_25150	CLHUN_06640	Putative glycosyl transferase.	1,4-alpha-glucan branching enzyme GlgB; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.	0.870
OPX43577.1	gmhB	CLHUN_25150	CLHUN_15130	Putative glycosyl transferase.	D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase.	0.758
OPX43577.1	hddC_1	CLHUN_25150	CLHUN_07990	Putative glycosyl transferase.	D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase.	0.752
OPX43577.1	hddC_2	CLHUN_25150	CLHUN_26250	Putative glycosyl transferase.	D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase.	0.755
OPX43577.1	mshA	CLHUN_25150	CLHUN_25140	Putative glycosyl transferase.	D-inositol-3-phosphate glycosyltransferase.	0.769
OPX43577.1	wbpI_2	CLHUN_25150	CLHUN_25160	Putative glycosyl transferase.	UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronate 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family.	0.918
OPX43581.1	OPX43577.1	CLHUN_25190	CLHUN_25150	Hypothetical protein.	Putative glycosyl transferase.	0.686
OPX43581.1	capD_2	CLHUN_25190	CLHUN_25180	Hypothetical protein.	UDP-glucose 4-epimerase.	0.686
OPX43581.1	fcl_1	CLHUN_25190	CLHUN_25170	Hypothetical protein.	GDP-L-fucose synthase.	0.686
OPX43581.1	mshA	CLHUN_25190	CLHUN_25140	Hypothetical protein.	D-inositol-3-phosphate glycosyltransferase.	0.420
OPX43581.1	wbpI_2	CLHUN_25190	CLHUN_25160	Hypothetical protein.	UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronate 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family.	0.686
OPX46029.1	OPX43577.1	CLHUN_05040	CLHUN_25150	Alpha/beta hydrolase family protein.	Putative glycosyl transferase.	0.630
OPX46029.1	mshA	CLHUN_05040	CLHUN_25140	Alpha/beta hydrolase family protein.	D-inositol-3-phosphate glycosyltransferase.	0.630
capD_2	OPX43577.1	CLHUN_25180	CLHUN_25150	UDP-glucose 4-epimerase.	Putative glycosyl transferase.	0.841
capD_2	OPX43581.1	CLHUN_25180	CLHUN_25190	UDP-glucose 4-epimerase.	Hypothetical protein.	0.686
capD_2	fcl_1	CLHUN_25180	CLHUN_25170	UDP-glucose 4-epimerase.	GDP-L-fucose synthase.	0.992

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.794

expected number of edges:

11

PPI enrichment p-value:

9.54e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006730

One-carbon metabolic process

4 of 9

2.06

2.24

2.92e-05

GO:0000096

Sulfur amino acid metabolic process

4 of 15

1.84

1.92

7.83e-05

GO:0009066

Aspartate family amino acid metabolic process

5 of 31

1.62

1.86

2.92e-05

GO:0009067

Aspartate family amino acid biosynthetic process

4 of 20

1.71

1.69

0.00018

GO:0006555

Methionine metabolic process

3 of 7

2.04

1.65

0.00058

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004013

Adenosylhomocysteinase activity

3 of 3

2.41

1.79

0.00046

GO:0008172

S-methyltransferase activity

2 of 3

2.23

0.94

0.0180

GO:0019842

Vitamin binding

3 of 36

1.33

0.65

0.0389

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1144

Cysteine and methionine metabolism, and Homoserine kinase activity

10 of 21

2.09

6.38

3.43e-17

CL:1146

Cysteine and methionine metabolism, and Homoserine kinase activity

8 of 15

2.14

5.46

1.68e-13

CL:1147

Adenosylhomocysteinase-like, and Threonine biosynthetic process

7 of 10

2.26

5.36

2.37e-12

CL:1150

Homocysteine-binding domain, and Adenosylhomocysteinase-like

5 of 5

2.41

4.12

7.08e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ttr00270

Cysteine and methionine metabolism

9 of 32

1.86

4.62

5.66e-14

ttr00450

Selenocompound metabolism

3 of 10

1.89

1.76

0.00023

ttr00260

Glycine, serine and threonine metabolism

4 of 26

1.6

1.71

7.83e-05

ttr01230

Biosynthesis of amino acids

6 of 104

1.17

1.25

3.82e-05

ttr01110

Biosynthesis of secondary metabolites

7 of 253

0.85

0.76

0.00023

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0554

One-carbon metabolism

3 of 7

2.04

1.55

0.00092

KW-0486

Methionine biosynthesis

2 of 4

2.11

0.93

0.0183

KW-0520

NAD

3 of 38

1.31

0.71

0.0256

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02574

Homocysteine S-methyltransferase

2 of 2

2.41

0.79

0.0365

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042172

Adenosylhomocysteinase-like superfamily

3 of 3

2.41

1.61

0.0010

IPR020082

S-adenosyl-L-homocysteine hydrolase, conserved site

3 of 3

2.41

1.61

0.0010

IPR015878

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

2.41

1.61

0.0010

IPR000043

Adenosylhomocysteinase-like

3 of 3

2.41

1.61

0.0010

IPR036589

Homocysteine-binding domain superfamily

2 of 2

2.41

0.93

0.0196

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00997

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

2.41

2.14

9.34e-05

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