STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
iscSCysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (393 aa)    
Predicted Functional Partners:
iscU
Iron-sulfur cluster assembly scaffold protein IscU.
 
 0.999
cdr
Coenzyme A disulfide reductase; Belongs to the sulfur carrier protein TusA family.
   
 0.990
OPX44776.1
Hypothetical protein.
  
 0.988
cymR
HTH-type transcriptional regulator CymR.
 
 0.974
thiI
Putative tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
 
 0.958
OPX42296.1
Hypothetical protein; Belongs to the sulfur carrier protein TusA family.
   
 0.938
glpE
Thiosulfate sulfurtransferase GlpE.
  
 0.904
nifS
Cysteine desulfurase NifS.
  
  
 
0.852
moeZ_1
Putative adenylyltransferase/sulfurtransferase MoeZ.
   
 0.826
iscR
HTH-type transcriptional regulator IscR.
 
 
 0.826
Your Current Organism:
Ruminiclostridium hungatei
NCBI taxonomy Id: 48256
Other names: ATCC 700212, Clostridium hungatei, Clostridium hungatei Monserrate et al. 2001, DSM 14427, R. hungatei, strain AD
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.