STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A183MPI9CNNM transmembrane domain-containing protein. (474 aa)    
Predicted Functional Partners:
SMRZ_LOCUS5303
Uncharacterized protein.
  
 
 0.836
A0A183MWF5
GMPS ATP-PPase domain-containing protein.
  
 
 0.836
SMRZ_LOCUS3723
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
    
 0.810
A0A183N9D2
Uncharacterized protein.
    
 0.774
A0A183N9L0
Uncharacterized protein; Belongs to the 5'-nucleotidase family.
    
 0.774
A0A183N7D7
Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.769
A0A183MRM8
TYR_PHOSPHATASE_2 domain-containing protein.
    
 
 0.763
SMRZ_LOCUS3407
Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.696
A0A183M5L8
Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
  
 
 0.696
SMRZ_LOCUS9311
TYR_PHOSPHATASE_2 domain-containing protein.
    
 
 0.678
Your Current Organism:
Schistosoma margrebowiei
NCBI taxonomy Id: 48269
Other names: S. margrebowiei
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