A0A163K561 protein (Absidia glauca) - STRING interaction network

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A163K561

BZIP domain-containing protein. (613 aa)

Predicted Functional Partners:

A0A163MFI1

0.874

A0A168SM81

0.874

A0A163J4F0

0.777

A0A163JMZ6

0.760

A0A163UZ10

0.749

A0A163URK4

0.695

A0A168NFT5

0.695

A0A163IVR7

0.689

A0A168PQ35

0.689

A0A168QRH0

0.689

Your Current Organism:

Absidia glauca

NCBI taxonomy Id: 4829
Other names: A. glauca, CBS 101.08, MUCL 10044

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A163IVR7	A0A163JMZ6	Uncharacterized protein.	Uncharacterized protein.	0.732
A0A163IVR7	A0A163K561	Uncharacterized protein.	BZIP domain-containing protein.	0.689
A0A163J4F0	A0A163JMZ6	TAF4 domain-containing protein.	Uncharacterized protein.	0.748
A0A163J4F0	A0A163K561	TAF4 domain-containing protein.	BZIP domain-containing protein.	0.777
A0A163J4F0	A0A163MFI1	TAF4 domain-containing protein.	BZIP domain-containing protein.	0.816
A0A163J4F0	A0A168SM81	TAF4 domain-containing protein.	BZIP domain-containing protein.	0.816
A0A163JMZ6	A0A163IVR7	Uncharacterized protein.	Uncharacterized protein.	0.732
A0A163JMZ6	A0A163J4F0	Uncharacterized protein.	TAF4 domain-containing protein.	0.748
A0A163JMZ6	A0A163K561	Uncharacterized protein.	BZIP domain-containing protein.	0.760
A0A163JMZ6	A0A163MFI1	Uncharacterized protein.	BZIP domain-containing protein.	0.787
A0A163JMZ6	A0A168PQ35	Uncharacterized protein.	Uncharacterized protein.	0.732
A0A163JMZ6	A0A168QRH0	Uncharacterized protein.	Uncharacterized protein.	0.732
A0A163JMZ6	A0A168SM81	Uncharacterized protein.	BZIP domain-containing protein.	0.787
A0A163K561	A0A163IVR7	BZIP domain-containing protein.	Uncharacterized protein.	0.689
A0A163K561	A0A163J4F0	BZIP domain-containing protein.	TAF4 domain-containing protein.	0.777
A0A163K561	A0A163JMZ6	BZIP domain-containing protein.	Uncharacterized protein.	0.760
A0A163K561	A0A163MFI1	BZIP domain-containing protein.	BZIP domain-containing protein.	0.874
A0A163K561	A0A163URK4	BZIP domain-containing protein.	Serine/threonine-protein phosphatase.	0.695
A0A163K561	A0A163UZ10	BZIP domain-containing protein.	Uncharacterized protein.	0.749
A0A163K561	A0A168NFT5	BZIP domain-containing protein.	Serine/threonine-protein phosphatase.	0.695

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.91

expected number of edges:

30

PPI enrichment p-value:

0.225

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019752

Carboxylic acid metabolic process

8 of 481

1.29

1.56

5.26e-06

GO:0006631

Fatty acid metabolic process

5 of 202

1.46

1.29

0.00075

GO:0001561

Fatty acid alpha-oxidation

2 of 4

2.77

1.14

0.0085

GO:0019395

Fatty acid oxidation

3 of 51

1.84

1.05

0.0087

GO:0046394

Carboxylic acid biosynthetic process

4 of 152

1.49

0.98

0.0069

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016614

Oxidoreductase activity, acting on CH-OH group of donors

5 of 89

1.82

2.12

2.02e-05

GO:0004449

Isocitrate dehydrogenase (NAD+) activity

2 of 2

3.07

1.29

0.0048

GO:0003973

(S)-2-hydroxy-acid oxidase activity

2 of 3

2.89

1.26

0.0053

GO:0010181

FMN binding

2 of 10

2.37

0.99

0.0152

GO:0016616

Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

3 of 84

1.62

0.89

0.0152

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005777

Peroxisome

5 of 86

1.83

2.27

8.81e-06

GO:0005962

Mitochondrial isocitrate dehydrogenase complex (NAD+)

2 of 2

3.07

1.53

0.0017

GO:0005782

Peroxisomal matrix

2 of 11

2.33

1.08

0.0101

GO:0005739

Mitochondrion

6 of 928

0.88

0.6

0.0101

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5496

Mixed, incl. Valine, leucine and isoleucine degradation, and Retinol metabolism

5 of 117

1.7

1.79

8.54e-05

CL:5638

Mixed, incl. Ethanol oxidation, and Acylphosphatase

3 of 15

2.37

1.75

0.00052

CL:5500

Mixed, incl. Valine, leucine and isoleucine degradation, and Lipid oxidation

4 of 84

1.75

1.51

0.00059

CL:5186

Citrate cycle (TCA cycle), and Glyoxylate metabolism and glycine degradation

3 of 39

1.95

1.3

0.0029

CL:5220

Isopropylmalate dehydrogenase-like domain, and Citrate metabolic process

2 of 6

2.59

1.14

0.0085

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

padl04146

Peroxisome

4 of 55

1.93

2.21

2.14e-05

padl01210

2-Oxocarboxylic acid metabolism

2 of 9

2.41

1.36

0.0030

padl01230

Biosynthesis of amino acids

2 of 43

1.74

0.74

0.0357

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9033241

Peroxisomal protein import

6 of 66

2.03

3.49

1.82e-08

MAP-390918

Peroxisomal lipid metabolism

4 of 29

2.21

2.62

6.32e-06

MAP-9609507

Protein localization

6 of 126

1.75

2.6

3.75e-07

MAP-71406

Pyruvate metabolism and Citric Acid (TCA) cycle

3 of 44

1.9

1.36

0.0020

MAP-193775

Synthesis of bile acids and bile salts via 24-hydroxycholesterol

2 of 6

2.59

1.3

0.0043

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 7764

0.22

0.21

0.0354

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

5 of 74

1.9

2.43

4.75e-06

GOCC:0005962

Mitochondrial isocitrate dehydrogenase complex (NAD+)

2 of 2

3.07

1.52

0.0018

GOCC:0005782

Peroxisomal matrix

2 of 10

2.37

1.17

0.0070

GOCC:1990204

Oxidoreductase complex

3 of 70

1.7

1.07

0.0064

GOCC:0005739

Mitochondrion

5 of 588

1.0

0.69

0.0086

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0288

FMN

2 of 7

2.52

1.18

0.0069

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02515

CoA-transferase family III

2 of 2

3.07

1.23

0.0060

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037396

FMN hydroxy acid dehydrogenase domain

2 of 2

3.07

0.95

0.0197

IPR024084

Isopropylmalate dehydrogenase-like domain

2 of 3

2.89

0.95

0.0197

IPR023606

CoA-transferase family III domain 1 superfamily

2 of 2

3.07

0.95

0.0197

IPR012133

Alpha-hydroxy acid dehydrogenase, FMN-dependent

2 of 2

3.07

0.95

0.0197

IPR008259

FMN-dependent alpha-hydroxy acid dehydrogenase, active site

2 of 2

3.07

0.95

0.0197

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01329

Isocitrate/isopropylmalate dehydrogenase

2 of 3

2.89

1.31

0.0042

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