A0A163VEQ4 protein (Absidia glauca) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

A0A163VEQ4

PKS_ER domain-containing protein. (347 aa)

Predicted Functional Partners:

A0A163JWE7

0.540

A0A168RK64

0.540

A0A163MCK9

0.442

A0A168SBN4

0.442

A0A163JFD2

0.433

A0A163MMQ2

0.433

A0A163TCU4

0.433

A0A168KSP5

0.433

A0A168M4Y9

0.433

A0A168MA68

0.433

Your Current Organism:

Absidia glauca

NCBI taxonomy Id: 4829
Other names: A. glauca, CBS 101.08, MUCL 10044

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A163JFD2	A0A163VEQ4	Aldo_ket_red domain-containing protein.	PKS_ER domain-containing protein.	0.433
A0A163JWE7	A0A163VEQ4	Uncharacterized protein.	PKS_ER domain-containing protein.	0.540
A0A163MCK9	A0A163VEQ4	Uncharacterized protein.	PKS_ER domain-containing protein.	0.442
A0A163MMQ2	A0A163VEQ4	Aldo_ket_red domain-containing protein.	PKS_ER domain-containing protein.	0.433
A0A163TCU4	A0A163VEQ4	Aldo_ket_red domain-containing protein.	PKS_ER domain-containing protein.	0.433
A0A163VEQ4	A0A163JFD2	PKS_ER domain-containing protein.	Aldo_ket_red domain-containing protein.	0.433
A0A163VEQ4	A0A163JWE7	PKS_ER domain-containing protein.	Uncharacterized protein.	0.540
A0A163VEQ4	A0A163MCK9	PKS_ER domain-containing protein.	Uncharacterized protein.	0.442
A0A163VEQ4	A0A163MMQ2	PKS_ER domain-containing protein.	Aldo_ket_red domain-containing protein.	0.433
A0A163VEQ4	A0A163TCU4	PKS_ER domain-containing protein.	Aldo_ket_red domain-containing protein.	0.433
A0A163VEQ4	A0A168KSP5	PKS_ER domain-containing protein.	Aldo_ket_red domain-containing protein.	0.433
A0A163VEQ4	A0A168M4Y9	PKS_ER domain-containing protein.	Aldo_ket_red domain-containing protein.	0.433
A0A163VEQ4	A0A168MA68	PKS_ER domain-containing protein.	Aldo_ket_red domain-containing protein.	0.433
A0A163VEQ4	A0A168RK64	PKS_ER domain-containing protein.	Uncharacterized protein.	0.540
A0A163VEQ4	A0A168SBN4	PKS_ER domain-containing protein.	Uncharacterized protein.	0.442
A0A168KSP5	A0A163VEQ4	Aldo_ket_red domain-containing protein.	PKS_ER domain-containing protein.	0.433
A0A168M4Y9	A0A163VEQ4	Aldo_ket_red domain-containing protein.	PKS_ER domain-containing protein.	0.433
A0A168MA68	A0A163VEQ4	Aldo_ket_red domain-containing protein.	PKS_ER domain-containing protein.	0.433
A0A168RK64	A0A163VEQ4	Uncharacterized protein.	PKS_ER domain-containing protein.	0.540
A0A168SBN4	A0A163VEQ4	Uncharacterized protein.	PKS_ER domain-containing protein.	0.442

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.889

expected number of edges:

27

PPI enrichment p-value:

0.507

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044085

Cellular component biogenesis

8 of 1367

1.0

0.87

0.00060

GO:0042254

Ribosome biogenesis

4 of 250

1.44

0.8

0.0183

GO:0071840

Cellular component organization or biogenesis

9 of 2850

0.73

0.54

0.0049

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0099512

Supramolecular fiber

4 of 260

1.42

1.03

0.0040

GO:0043232

Intracellular non-membrane-bounded organelle

8 of 1801

0.88

0.73

0.00095

GO:0030017

Sarcomere

2 of 56

1.78

0.73

0.0401

GO:0031981

Nuclear lumen

5 of 929

0.96

0.62

0.0139

GO:0043229

Intracellular organelle

11 of 7022

0.43

0.34

0.0042

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7725

Mixed, incl. Single-stranded DNA endodeoxyribonuclease activity, and Protein desumoylation

3 of 26

2.29

1.52

0.0014

CL:7739

Mixed, incl. Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3, and Rix1 complex

2 of 5

2.83

1.24

0.0056

CL:7232

Preribosome, large subunit precursor

2 of 6

2.75

1.24

0.0056

CL:414

Mixed, incl. Tubulin, and Doublecortin

2 of 18

2.28

0.93

0.0189

CL:309

Mixed, incl. Tubulin, and EF-hand domain

3 of 174

1.47

0.73

0.0299

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8868773

rRNA processing in the nucleus and cytosol

4 of 133

1.71

1.41

0.0010

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

4 of 128

1.73

1.41

0.0010

MAP-72312

rRNA processing

4 of 157

1.64

1.37

0.0010

MAP-8953854

Metabolism of RNA

5 of 825

1.01

0.61

0.0208

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