STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaK-2DnaK family protein; KEGG: mbo:Mb0358 9.7e-16 dnaK; probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kda protein) (HSP70) K04043. (805 aa)    
Predicted Functional Partners:
htpG
ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: eci:UTI89_C0501 4.0e-73 htpG; chaperone HSP90, heat shock protein C 62.5 K04079; Psort location: Cytoplasmic, score: 9.26.
   
 0.991
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
 
 0.981
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
 
 0.975
dnaJ_2
DnaJ domain protein; KEGG: cme:CMJ043C 1.6e-07 phycocyanobilin lyase alpha subunit K02288; Psort location: Cytoplasmic, score: 9.97.
 
 0.954
djlA
DnaJ domain protein; KEGG: shn:Shewana3_0875 0.0062 formate dehydrogenase K00122; Psort location: Cytoplasmic, score: 8.96.
  
 0.919
rplP
Ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.
   
 0.915
rpfC_4
ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: bba:Bd3779 1.3e-36 hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.82.
  
 0.911
EEC54615.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.
  
 0.908
groL
Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.906
clpB_2
ATPase family associated with various cellular activities (AAA); KEGG: fth:FTH_0089 6.6e-133 clpB; endopeptidase Clp K01358; Psort location: Cytoplasmic, score: 9.97; Belongs to the ClpA/ClpB family.
  
 
 0.892
Your Current Organism:
Bacteroides eggerthii
NCBI taxonomy Id: 483216
Other names: B. eggerthii DSM 20697, Bacteroides eggerthii ATCC 27754, Bacteroides eggerthii DSM 20697, Bacteroides eggerthii str. DSM 20697, Bacteroides eggerthii strain DSM 20697
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