STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EEC58436.1KEGG: chy:CHY_1105 8.5e-19 3-isopropylmalate dehydratase, large subunit family protein K01703; Psort location: Cytoplasmic, score: 8.96. (110 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
 
 0.995
leuD-2
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
 
 0.995
EEC58435.1
KEGG: pfu:PF0938 4.2e-85 3-isopropylmalate dehydratase large subunit K01703; Psort location: Cytoplasmic, score: 8.96.
     0.989
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.972
nifJ
Pyruvate synthase; KEGG: tte:TTE0445 0. porA; Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit K03737.
  
 0.890
EEC58628.1
HMGL-like protein; KEGG: syw:SYNW0424 3.2e-19 possible HMGL-like family protein K01666.
  
 
 0.878
leuA
Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 
 0.878
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.793
pyk
Pyruvate kinase; KEGG: tte:TTE1815 7.4e-136 pykF; pyruvate kinase K00873; Psort location: Cytoplasmic, score: 8.96.
    
 0.787
EEC58243.1
Malic enzyme, NAD binding domain protein; KEGG: cpr:CPR_0140 1.8e-125 NAD-dependent malic enzyme K00027.
    
  0.779
Your Current Organism:
Bacteroides pectinophilus
NCBI taxonomy Id: 483218
Other names: Bacteroides pectinophilus ATCC 43243, [. pectinophilus ATCC 43243, [Bacteroides] pectinophilus ATCC 43243, [Bacteroides] pectinophilus str. ATCC 43243, [Bacteroides] pectinophilus strain ATCC 43243
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