Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
AJF06021.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1834 aa)    
Predicted Functional Partners:
AJF06475.1
Molecular chaperone Hsp90; Molecular chaperone. Has ATPase activity.
   
 0.732
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]
  
 
 0.646
AJF07352.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.614
AJF07358.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.609
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
  0.593
AJF05463.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
   
  0.593
AJF05464.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
   
  0.593
groEL
Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.552
AJF07836.1
Inner membrane cytochrome H; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.548
AJF05379.1
C- and b-type cytochrome L; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.546
Your Current Organism:
Geoalkalibacter subterraneus
NCBI taxonomy Id: 483547
Other names: DSM 23483, G. subterraneus, Geoalkalibacter subterraneus Greene et al. 2009, JCM 15104, KCTC 5626, strain Red1
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