STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDN43099.1Hypothetical protein; Belongs to the dihydrofolate reductase family. (331 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.930
folC
Folylpolyglutamate synthase; Product derived from UniProtKB/Swiss-Prot:Q05865;Gene name derived from UniProtKB/Swiss-Prot:Q05865;EC number derived from UniProtKB/Swiss-Prot:Q05865.
     
 0.925
metH
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.924
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
    
 0.922
purH
Bifunctional purine biosynthesis protein PurH; Product derived from UniProtKB/Swiss-Prot:Q6HPA0;Gene name derived from UniProtKB/Swiss-Prot:Q6HPA0;EC number derived from UniProtKB/Swiss-Prot:Q6HPA0.
    
 0.922
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
   
 
 0.920
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
     
 0.919
gcvH
Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family.
    
 0.896
ribD
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
    
 0.825
gltB
Glutamate synthase [NADPH] small chain; Product derived from UniProtKB/Swiss-Prot:O34399;Gene name derived from UniProtKB/Swiss-Prot:O34399;EC number derived from UniProtKB/Swiss-Prot:O34399.
    
  0.792
Your Current Organism:
Paenibacillus sp. P22
NCBI taxonomy Id: 483908
Other names: P. sp. P22
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