| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GlnA | TW91_0718 | TW91_1052 | TW91_0718 | Glutamine synthetase, type I. | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | 0.694 |
| GlnA | TW91_1535 | TW91_1052 | TW91_1535 | Glutamine synthetase, type I. | Rubredoxin. | 0.514 |
| GlnA | glnD | TW91_1052 | TW91_0134 | Glutamine synthetase, type I. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.566 |
| GlnA | glnE | TW91_1052 | TW91_0193 | Glutamine synthetase, type I. | [glutamate-ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tran [...] | 0.812 |
| HrpA | TW91_1087 | TW91_1086 | TW91_1087 | ATP-dependent helicase HrpA. | Hypothetical protein. | 0.976 |
| HrpA | glnE | TW91_1086 | TW91_0193 | ATP-dependent helicase HrpA. | [glutamate-ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tran [...] | 0.414 |
| TW91_0192 | glnE | TW91_0192 | TW91_0193 | Putative Fe(2+)-trafficking protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. | [glutamate-ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tran [...] | 0.534 |
| TW91_0263 | glnE | TW91_0263 | TW91_0193 | Potassium-efflux system protein; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | [glutamate-ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tran [...] | 0.527 |
| TW91_0718 | GlnA | TW91_0718 | TW91_1052 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Glutamine synthetase, type I. | 0.694 |
| TW91_0718 | TW91_1535 | TW91_0718 | TW91_1535 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Rubredoxin. | 0.569 |
| TW91_0718 | glnD | TW91_0718 | TW91_0134 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.983 |
| TW91_0718 | glnE | TW91_0718 | TW91_0193 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | [glutamate-ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tran [...] | 0.509 |
| TW91_0984 | glnE | TW91_0984 | TW91_0193 | Sugar isomerase, KpsF/GutQ family; Belongs to the SIS family. GutQ/KpsF subfamily. | [glutamate-ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tran [...] | 0.495 |
| TW91_1087 | HrpA | TW91_1087 | TW91_1086 | Hypothetical protein. | ATP-dependent helicase HrpA. | 0.976 |
| TW91_1087 | glnE | TW91_1087 | TW91_0193 | Hypothetical protein. | [glutamate-ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tran [...] | 0.559 |
| TW91_1535 | GlnA | TW91_1535 | TW91_1052 | Rubredoxin. | Glutamine synthetase, type I. | 0.514 |
| TW91_1535 | TW91_0718 | TW91_1535 | TW91_0718 | Rubredoxin. | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | 0.569 |
| TW91_1535 | TW91_1846 | TW91_1535 | TW91_1846 | Rubredoxin. | Antioxidant, AhpC/TSA family. | 0.530 |
| TW91_1535 | glnD | TW91_1535 | TW91_0134 | Rubredoxin. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.508 |
| TW91_1535 | glnE | TW91_1535 | TW91_0193 | Rubredoxin. | [glutamate-ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tran [...] | 0.445 |
