HpaC protein (Neisseria flavescens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HpaC

4-hydroxyphenylacetate 3-monooxygenase, reductase component. (128 aa)

Predicted Functional Partners:

RibF

0.902

ubiX

0.900

TW91_1661

0.900

HpaR

0.619

ribB

0.556

TW91_0432

0.543

Your Current Organism:

Neisseria flavescens

NCBI taxonomy Id: 484
Other names: ATCC 13120, CCUG 17913, CCUG 345, CIP 73.15, DSM 17633, LMG 5297, LMG:5297, NCTC 8263

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HpaC	HpaR	TW91_0431	TW91_0430	4-hydroxyphenylacetate 3-monooxygenase, reductase component.	Homoprotocatechuate degradation operon regulator, HpaR.	0.619
HpaC	RibF	TW91_0431	TW91_1542	4-hydroxyphenylacetate 3-monooxygenase, reductase component.	Riboflavin biosynthesis protein RibF; Belongs to the ribF family.	0.902
HpaC	TW91_0432	TW91_0431	TW91_0432	4-hydroxyphenylacetate 3-monooxygenase, reductase component.	Sugar-phosphate nucleotidyl transferase.	0.543
HpaC	TW91_1661	TW91_0431	TW91_1661	4-hydroxyphenylacetate 3-monooxygenase, reductase component.	Riboflavin synthase, alpha subunit.	0.900
HpaC	ribB	TW91_0431	TW91_1386	4-hydroxyphenylacetate 3-monooxygenase, reductase component.	3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.	0.556
HpaC	ubiX	TW91_0431	TW91_0883	4-hydroxyphenylacetate 3-monooxygenase, reductase component.	Phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.	0.900
HpaR	HpaC	TW91_0430	TW91_0431	Homoprotocatechuate degradation operon regulator, HpaR.	4-hydroxyphenylacetate 3-monooxygenase, reductase component.	0.619
RibF	HpaC	TW91_1542	TW91_0431	Riboflavin biosynthesis protein RibF; Belongs to the ribF family.	4-hydroxyphenylacetate 3-monooxygenase, reductase component.	0.902
RibF	TW91_1661	TW91_1542	TW91_1661	Riboflavin biosynthesis protein RibF; Belongs to the ribF family.	Riboflavin synthase, alpha subunit.	0.945
RibF	ribB	TW91_1542	TW91_1386	Riboflavin biosynthesis protein RibF; Belongs to the ribF family.	3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.	0.702
TW91_0432	HpaC	TW91_0432	TW91_0431	Sugar-phosphate nucleotidyl transferase.	4-hydroxyphenylacetate 3-monooxygenase, reductase component.	0.543
TW91_1661	HpaC	TW91_1661	TW91_0431	Riboflavin synthase, alpha subunit.	4-hydroxyphenylacetate 3-monooxygenase, reductase component.	0.900
TW91_1661	RibF	TW91_1661	TW91_1542	Riboflavin synthase, alpha subunit.	Riboflavin biosynthesis protein RibF; Belongs to the ribF family.	0.945
TW91_1661	ribB	TW91_1661	TW91_1386	Riboflavin synthase, alpha subunit.	3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.	0.999
ribB	HpaC	TW91_1386	TW91_0431	3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.	4-hydroxyphenylacetate 3-monooxygenase, reductase component.	0.556
ribB	RibF	TW91_1386	TW91_1542	3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.	Riboflavin biosynthesis protein RibF; Belongs to the ribF family.	0.702
ribB	TW91_1661	TW91_1386	TW91_1661	3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.	Riboflavin synthase, alpha subunit.	0.999
ubiX	HpaC	TW91_0883	TW91_0431	Phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.	4-hydroxyphenylacetate 3-monooxygenase, reductase component.	0.900