| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TW91_0415 | TW91_0597 | TW91_0415 | TW91_0597 | ATP-grasp domain protein. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.737 |
| TW91_0415 | TW91_0836 | TW91_0415 | TW91_0836 | ATP-grasp domain protein. | Transmembrane transport protein. | 0.521 |
| TW91_0415 | TW91_1569 | TW91_0415 | TW91_1569 | ATP-grasp domain protein. | CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3- dehydrase reductase. | 0.816 |
| TW91_0415 | purL | TW91_0415 | TW91_1341 | ATP-grasp domain protein. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.635 |
| TW91_0415 | pyrB | TW91_0415 | TW91_0234 | ATP-grasp domain protein. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.812 |
| TW91_0415 | pyrD | TW91_0415 | TW91_1345 | ATP-grasp domain protein. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. | 0.737 |
| TW91_0415 | pyrE | TW91_0415 | TW91_1120 | ATP-grasp domain protein. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.832 |
| TW91_0415 | pyrF | TW91_0415 | TW91_1433 | ATP-grasp domain protein. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.811 |
| TW91_0597 | TW91_0415 | TW91_0597 | TW91_0415 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | ATP-grasp domain protein. | 0.737 |
| TW91_0597 | TW91_0836 | TW91_0597 | TW91_0836 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Transmembrane transport protein. | 0.505 |
| TW91_0597 | TW91_1569 | TW91_0597 | TW91_1569 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3- dehydrase reductase. | 0.940 |
| TW91_0597 | carB | TW91_0597 | TW91_0976 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. | 0.822 |
| TW91_0597 | purL | TW91_0597 | TW91_1341 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.638 |
| TW91_0597 | pyrB | TW91_0597 | TW91_0234 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.812 |
| TW91_0597 | pyrD | TW91_0597 | TW91_1345 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. | 0.900 |
| TW91_0597 | pyrE | TW91_0597 | TW91_1120 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.986 |
| TW91_0597 | pyrF | TW91_0597 | TW91_1433 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.812 |
| TW91_0836 | TW91_0415 | TW91_0836 | TW91_0415 | Transmembrane transport protein. | ATP-grasp domain protein. | 0.521 |
| TW91_0836 | TW91_0597 | TW91_0836 | TW91_0597 | Transmembrane transport protein. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.505 |
| TW91_0836 | TW91_0837 | TW91_0836 | TW91_0837 | Transmembrane transport protein. | N6-adenine-specific DNA methylase; Belongs to the methyltransferase superfamily. | 0.524 |