| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HemB | TW91_1212 | TW91_0143 | TW91_1212 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III synthase. | 0.890 |
| HemB | cysG | TW91_0143 | TW91_1273 | Porphobilinogen synthase; Belongs to the ALAD family. | Siroheme synthase 1; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.932 |
| HemB | hemA | TW91_0143 | TW91_1786 | Porphobilinogen synthase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.864 |
| HemB | hemC | TW91_0143 | TW91_1780 | Porphobilinogen synthase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
| HemB | hemE | TW91_0143 | TW91_1209 | Porphobilinogen synthase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.761 |
| HemB | hemL | TW91_0143 | TW91_0112 | Porphobilinogen synthase; Belongs to the ALAD family. | Glutamate-1-semialdehyde-2,1-aminomutase. | 0.991 |
| TW91_1210 | TW91_1211 | TW91_1210 | TW91_1211 | HemY protein. | uroporphyrinogen-III synthase. | 0.976 |
| TW91_1210 | TW91_1212 | TW91_1210 | TW91_1212 | HemY protein. | uroporphyrinogen-III synthase. | 0.921 |
| TW91_1210 | TW91_1552 | TW91_1210 | TW91_1552 | HemY protein. | Hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | 0.764 |
| TW91_1210 | hemE | TW91_1210 | TW91_1209 | HemY protein. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.566 |
| TW91_1211 | TW91_1210 | TW91_1211 | TW91_1210 | uroporphyrinogen-III synthase. | HemY protein. | 0.976 |
| TW91_1211 | TW91_1212 | TW91_1211 | TW91_1212 | uroporphyrinogen-III synthase. | uroporphyrinogen-III synthase. | 0.884 |
| TW91_1211 | TW91_1552 | TW91_1211 | TW91_1552 | uroporphyrinogen-III synthase. | Hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | 0.502 |
| TW91_1211 | hemC | TW91_1211 | TW91_1780 | uroporphyrinogen-III synthase. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.448 |
| TW91_1211 | hemE | TW91_1211 | TW91_1209 | uroporphyrinogen-III synthase. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.503 |
| TW91_1212 | HemB | TW91_1212 | TW91_0143 | uroporphyrinogen-III synthase. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.890 |
| TW91_1212 | TW91_1210 | TW91_1212 | TW91_1210 | uroporphyrinogen-III synthase. | HemY protein. | 0.921 |
| TW91_1212 | TW91_1211 | TW91_1212 | TW91_1211 | uroporphyrinogen-III synthase. | uroporphyrinogen-III synthase. | 0.884 |
| TW91_1212 | TW91_1552 | TW91_1212 | TW91_1552 | uroporphyrinogen-III synthase. | Hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | 0.655 |
| TW91_1212 | cysG | TW91_1212 | TW91_1273 | uroporphyrinogen-III synthase. | Siroheme synthase 1; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.758 |
