| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AmpD | TW91_0993 | TW91_1553 | TW91_0993 | Protein AmpD. | MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG. | 0.572 |
| AmpD | TW91_1304 | TW91_1553 | TW91_1304 | Protein AmpD. | Membrane peptidase. | 0.407 |
| AmpD | TW91_1551 | TW91_1553 | TW91_1551 | Protein AmpD. | DNA ligase, NAD-dependent. | 0.414 |
| AmpD | TW91_1552 | TW91_1553 | TW91_1552 | Protein AmpD. | Hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | 0.471 |
| AmpD | TW91_1708 | TW91_1553 | TW91_1708 | Protein AmpD. | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.540 |
| AmpD | ligA | TW91_1553 | TW91_1550 | Protein AmpD. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.414 |
| AmpD | mltG | TW91_1553 | TW91_1554 | Protein AmpD. | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.623 |
| AmpD | mpl | TW91_1553 | TW91_0717 | Protein AmpD. | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. | 0.556 |
| AmpD | nagZ | TW91_1553 | TW91_1783 | Protein AmpD. | Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.526 |
| AmpD | tmk | TW91_1553 | TW91_1555 | Protein AmpD. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.473 |
| TW91_0993 | AmpD | TW91_0993 | TW91_1553 | MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG. | Protein AmpD. | 0.572 |
| TW91_0993 | TW91_1708 | TW91_0993 | TW91_1708 | MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG. | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.492 |
| TW91_0993 | nagZ | TW91_0993 | TW91_1783 | MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG. | Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.532 |
| TW91_1304 | AmpD | TW91_1304 | TW91_1553 | Membrane peptidase. | Protein AmpD. | 0.407 |
| TW91_1551 | AmpD | TW91_1551 | TW91_1553 | DNA ligase, NAD-dependent. | Protein AmpD. | 0.414 |
| TW91_1551 | TW91_1552 | TW91_1551 | TW91_1552 | DNA ligase, NAD-dependent. | Hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | 0.694 |
| TW91_1551 | ligA | TW91_1551 | TW91_1550 | DNA ligase, NAD-dependent. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.994 |
| TW91_1551 | mltG | TW91_1551 | TW91_1554 | DNA ligase, NAD-dependent. | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.403 |
| TW91_1552 | AmpD | TW91_1552 | TW91_1553 | Hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | Protein AmpD. | 0.471 |
| TW91_1552 | TW91_1551 | TW91_1552 | TW91_1551 | Hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | DNA ligase, NAD-dependent. | 0.694 |