| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RpoA | TW91_0773 | TW91_0044 | TW91_0773 | DNA-directed RNA polymerase, alpha subunit. | DNA-directed RNA polymerase, beta' subunit. | 0.982 |
| RpoA | dksA | TW91_0044 | TW91_0200 | DNA-directed RNA polymerase, alpha subunit. | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. | 0.567 |
| RpoA | greB | TW91_0044 | TW91_1592 | DNA-directed RNA polymerase, alpha subunit. | Transcription elongation factor GreB; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. | 0.832 |
| RpoA | rpoB | TW91_0044 | TW91_0775 | DNA-directed RNA polymerase, alpha subunit. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.998 |
| RpoA | rpoC | TW91_0044 | TW91_0772 | DNA-directed RNA polymerase, alpha subunit. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.980 |
| RpoA | rpoZ | TW91_0044 | TW91_1888 | DNA-directed RNA polymerase, alpha subunit. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.995 |
| RpoA | rpsO | TW91_0044 | TW91_1897 | DNA-directed RNA polymerase, alpha subunit. | Ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. | 0.978 |
| RpoA | topA | TW91_0044 | TW91_0216 | DNA-directed RNA polymerase, alpha subunit. | DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superc [...] | 0.958 |
| TW91_0773 | RpoA | TW91_0773 | TW91_0044 | DNA-directed RNA polymerase, beta' subunit. | DNA-directed RNA polymerase, alpha subunit. | 0.982 |
| TW91_0773 | dksA | TW91_0773 | TW91_0200 | DNA-directed RNA polymerase, beta' subunit. | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. | 0.663 |
| TW91_0773 | greB | TW91_0773 | TW91_1592 | DNA-directed RNA polymerase, beta' subunit. | Transcription elongation factor GreB; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. | 0.738 |
| TW91_0773 | rpoB | TW91_0773 | TW91_0775 | DNA-directed RNA polymerase, beta' subunit. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.999 |
| TW91_0773 | rpoC | TW91_0773 | TW91_0772 | DNA-directed RNA polymerase, beta' subunit. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.994 |
| TW91_0773 | rpoZ | TW91_0773 | TW91_1888 | DNA-directed RNA polymerase, beta' subunit. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.903 |
| TW91_0773 | rpsO | TW91_0773 | TW91_1897 | DNA-directed RNA polymerase, beta' subunit. | Ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. | 0.546 |
| TW91_0773 | topA | TW91_0773 | TW91_0216 | DNA-directed RNA polymerase, beta' subunit. | DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superc [...] | 0.952 |
| dksA | RpoA | TW91_0200 | TW91_0044 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. | DNA-directed RNA polymerase, alpha subunit. | 0.567 |
| dksA | TW91_0773 | TW91_0200 | TW91_0773 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. | DNA-directed RNA polymerase, beta' subunit. | 0.663 |
| dksA | greB | TW91_0200 | TW91_1592 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. | Transcription elongation factor GreB; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. | 0.577 |
| dksA | guaB | TW91_0200 | TW91_1655 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.602 |
