| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AJR24820.1 | argS | TZ53_14910 | TZ53_01035 | lysyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.952 |
| AJR24820.1 | guaA | TZ53_14910 | TZ53_10820 | lysyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.980 |
| AJR24820.1 | guaB | TZ53_14910 | TZ53_14360 | lysyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.678 |
| AJR24820.1 | pyrG | TZ53_14910 | TZ53_15905 | lysyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.726 |
| AJR24820.1 | rplA | TZ53_14910 | TZ53_13970 | lysyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.739 |
| AJR24820.1 | tuf | TZ53_14910 | TZ53_11290 | lysyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. | 0.796 |
| AJR26046.1 | guaA | TZ53_22165 | TZ53_10820 | Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.977 |
| AJR26046.1 | guaB | TZ53_22165 | TZ53_14360 | Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.965 |
| apt | gmk | TZ53_02340 | TZ53_15505 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.971 |
| apt | guaA | TZ53_02340 | TZ53_10820 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.995 |
| apt | guaB | TZ53_02340 | TZ53_14360 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.688 |
| apt | map | TZ53_02340 | TZ53_19670 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.451 |
| apt | pyrG | TZ53_02340 | TZ53_15905 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.552 |
| apt | rplA | TZ53_02340 | TZ53_13970 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.400 |
| argS | AJR24820.1 | TZ53_01035 | TZ53_14910 | arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | lysyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.952 |
| argS | gmk | TZ53_01035 | TZ53_15505 | arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.646 |
| argS | guaA | TZ53_01035 | TZ53_10820 | arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.976 |
| argS | guaB | TZ53_01035 | TZ53_14360 | arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.478 |
| argS | map | TZ53_01035 | TZ53_19670 | arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.425 |
| argS | pyrG | TZ53_01035 | TZ53_15905 | arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.856 |
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