purU protein (Sphingobium sp. YBL2) - STRING interaction network

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purU

Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)

Predicted Functional Partners:

folD

0.965

glyA

0.942

purN

0.929

AJR26069.1

0.927

purH

0.916

AJR25724.1

0.916

AJR22660.1

0.911

AJR22661.1

0.906

AJR23689.1

0.906

AJR23883.1

0.905

Your Current Organism:

Sphingobium sp. YBL2

NCBI taxonomy Id: 484429
Other names: S. sp. YBL2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJR22660.1	AJR22661.1	TZ53_01510	TZ53_01515	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AJR22660.1	AJR25724.1	TZ53_01510	TZ53_20240	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.913
AJR22660.1	AJR26069.1	TZ53_01510	TZ53_00870	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
AJR22660.1	glyA	TZ53_01510	TZ53_17200	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.930
AJR22660.1	purH	TZ53_01510	TZ53_10305	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.911
AJR22660.1	purN	TZ53_01510	TZ53_01545	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.	0.906
AJR22660.1	purU	TZ53_01510	TZ53_16560	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).	0.911
AJR22661.1	AJR22660.1	TZ53_01515	TZ53_01510	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AJR22661.1	AJR25724.1	TZ53_01515	TZ53_20240	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.906
AJR22661.1	AJR26069.1	TZ53_01515	TZ53_00870	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.917
AJR22661.1	glyA	TZ53_01515	TZ53_17200	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.930
AJR22661.1	purH	TZ53_01515	TZ53_10305	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.902
AJR22661.1	purN	TZ53_01515	TZ53_01545	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.	0.901
AJR22661.1	purU	TZ53_01515	TZ53_16560	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).	0.906
AJR23689.1	AJR23883.1	TZ53_08140	TZ53_09255	Formimidoylglutamase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP synthase subunit E; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
AJR23689.1	purU	TZ53_08140	TZ53_16560	Formimidoylglutamase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).	0.906
AJR23883.1	AJR23689.1	TZ53_09255	TZ53_08140	ATP synthase subunit E; Derived by automated computational analysis using gene prediction method: Protein Homology.	Formimidoylglutamase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
AJR23883.1	glyA	TZ53_09255	TZ53_17200	ATP synthase subunit E; Derived by automated computational analysis using gene prediction method: Protein Homology.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.665
AJR23883.1	purU	TZ53_09255	TZ53_16560	ATP synthase subunit E; Derived by automated computational analysis using gene prediction method: Protein Homology.	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).	0.905
AJR25724.1	AJR22660.1	TZ53_20240	TZ53_01510	Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.913