| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AJR22540.1 | trmJ | TZ53_00800 | TZ53_17190 | Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. | rRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.447 |
| AJR24985.1 | AJR25547.1 | TZ53_15890 | TZ53_19225 | Peptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.535 |
| AJR24985.1 | trmJ | TZ53_15890 | TZ53_17190 | Peptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | rRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.449 |
| AJR25547.1 | AJR24985.1 | TZ53_19225 | TZ53_15890 | ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Peptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.535 |
| AJR25547.1 | trmJ | TZ53_19225 | TZ53_17190 | ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | rRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.420 |
| cysS | glyA | TZ53_02670 | TZ53_17200 | cysteinyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.429 |
| cysS | trmJ | TZ53_02670 | TZ53_17190 | cysteinyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. | rRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.526 |
| glyA | cysS | TZ53_17200 | TZ53_02670 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | cysteinyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.429 |
| glyA | nrdR | TZ53_17200 | TZ53_17195 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | NrdR family transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.867 |
| glyA | trmJ | TZ53_17200 | TZ53_17190 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | rRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.409 |
| nrdR | glyA | TZ53_17195 | TZ53_17200 | NrdR family transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.867 |
| nrdR | trmJ | TZ53_17195 | TZ53_17190 | NrdR family transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | rRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.439 |
| rlmE | trmB | TZ53_11205 | TZ53_21175 | Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | tRNA (guanine-N7)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | 0.503 |
| rlmE | trmJ | TZ53_11205 | TZ53_17190 | Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | rRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.436 |
| rnhB | trmD | TZ53_13840 | TZ53_21975 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | tRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. | 0.513 |
| rnhB | trmJ | TZ53_13840 | TZ53_17190 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | rRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.601 |
| trmB | rlmE | TZ53_21175 | TZ53_11205 | tRNA (guanine-N7)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | 0.503 |
| trmB | trmD | TZ53_21175 | TZ53_21975 | tRNA (guanine-N7)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | tRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. | 0.426 |
| trmB | trmJ | TZ53_21175 | TZ53_17190 | tRNA (guanine-N7)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | rRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.453 |
| trmD | rnhB | TZ53_21975 | TZ53_13840 | tRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.513 |