PYK1_2 protein (Rhizopus stolonifer) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

PYK1_2

Pyruvate kinase. (68 aa)

Predicted Functional Partners:

RPL5

0.901

CU098_007495

0.890

RPS15_1

0.883

CU098_010580

0.883

RPS15_2

0.883

CU098_013043

0.883

RPL32

0.880

RPL35

0.875

PGK1_1

0.863

PGK1_2

0.863

Your Current Organism:

Rhizopus stolonifer

NCBI taxonomy Id: 4846
Other names: Mucor stolonifer, R. stolonifer, Rhizopus nigricans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CU098_007495	CU098_010580	A0A367IUS6	A0A367KFX9	Malate dehydrogenase.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.900
CU098_007495	CU098_013043	A0A367IUS6	A0A367KT16	Malate dehydrogenase.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.900
CU098_007495	PGK1_1	A0A367IUS6	A0A367JLX3	Malate dehydrogenase.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.667
CU098_007495	PGK1_2	A0A367IUS6	A0A367KLY9	Malate dehydrogenase.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.667
CU098_007495	PYK1_2	A0A367IUS6	A0A367IXN9	Malate dehydrogenase.	Pyruvate kinase.	0.890
CU098_007495	RPL35	A0A367IUS6	A0A367J929	Malate dehydrogenase.	60S ribosomal protein L35.	0.485
CU098_007495	RPS15_1	A0A367IUS6	A0A367JQ43	Malate dehydrogenase.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.780
CU098_007495	RPS15_2	A0A367IUS6	A0A367KKE9	Malate dehydrogenase.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.780
CU098_010580	CU098_007495	A0A367KFX9	A0A367IUS6	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Malate dehydrogenase.	0.900
CU098_010580	PGK1_1	A0A367KFX9	A0A367JLX3	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.976
CU098_010580	PGK1_2	A0A367KFX9	A0A367KLY9	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.976
CU098_010580	PYK1_2	A0A367KFX9	A0A367IXN9	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Pyruvate kinase.	0.883
CU098_010580	RPS15_1	A0A367KFX9	A0A367JQ43	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.733
CU098_010580	RPS15_2	A0A367KFX9	A0A367KKE9	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.733
CU098_013043	CU098_007495	A0A367KT16	A0A367IUS6	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Malate dehydrogenase.	0.900
CU098_013043	PGK1_1	A0A367KT16	A0A367JLX3	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.976
CU098_013043	PGK1_2	A0A367KT16	A0A367KLY9	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.976
CU098_013043	PYK1_2	A0A367KT16	A0A367IXN9	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Pyruvate kinase.	0.883
CU098_013043	RPS15_1	A0A367KT16	A0A367JQ43	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.733
CU098_013043	RPS15_2	A0A367KT16	A0A367KKE9	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.733

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.776

expected number of edges:

20

PPI enrichment p-value:

0.0147

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006366

Transcription by RNA polymerase II

5 of 89

1.75

1.88

6.53e-05

GO:0045471

Response to ethanol

2 of 3

2.83

1.2

0.0066

GO:0006636

Unsaturated fatty acid biosynthetic process

2 of 5

2.6

1.06

0.0116

GO:0042128

Nitrate assimilation

2 of 7

2.46

1.03

0.0133

GO:0000001

Mitochondrion inheritance

2 of 11

2.26

0.88

0.0235

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050464

Nitrate reductase (NADPH) activity

2 of 2

3.0

1.42

0.0027

GO:0004768

stearoyl-CoA 9-desaturase activity

2 of 2

3.0

1.42

0.0027

GO:0043546

Molybdopterin cofactor binding

2 of 5

2.6

1.37

0.0031

GO:0003899

DNA-directed 5-3 RNA polymerase activity

3 of 22

2.14

1.35

0.0027

GO:0030151

Molybdenum ion binding

2 of 8

2.4

1.21

0.0060

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005665

RNA polymerase II, core complex

5 of 12

2.62

4.58

1.74e-09

GO:0005736

RNA polymerase I complex

2 of 12

2.22

1.16

0.0069

GO:0005666

RNA polymerase III complex

2 of 17

2.07

1.04

0.0107

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3528

RNA polymerase II, core complex

3 of 7

2.63

2.03

0.00018

CL:3508

Mixed, incl. DNA-directed RNA polymerase complex, and Transcription elongation factor complex

5 of 130

1.59

0.00018

CL:14325

Oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor, and Nitrate assimilation

2 of 5

2.6

1.34

0.0035

CL:13072

Fatty acid metabolism

2 of 6

2.53

1.3

0.0042

CL:3733

RNA polymerase I complex

2 of 10

2.3

1.1

0.0092

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

5 of 41

2.09

3.35

7.00e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

5 of 27

2.27

3.57

6.18e-08

MAP-72086

mRNA Capping

5 of 29

2.24

3.54

6.18e-08

MAP-113418

Formation of the Early Elongation Complex

5 of 29

2.24

3.54

6.18e-08

MAP-75955

RNA Polymerase II Transcription Elongation

5 of 38

2.12

3.38

7.35e-08

MAP-6796648

TP53 Regulates Transcription of DNA Repair Genes

5 of 38

2.12

3.38

7.35e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

5 of 76

1.82

2.27

8.31e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

3 of 19

2.2

1.85

0.00028

KW-0275

Fatty acid biosynthesis

2 of 8

2.4

1.25

0.0050

KW-0249

Electron transport

2 of 17

2.07

1.12

0.0076

KW-0349

Heme

3 of 100

1.48

0.96

0.0076

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00174

Oxidoreductase molybdopterin binding domain

2 of 3

2.83

1.12

0.0096

PF00487

Fatty acid desaturase

2 of 10

2.3

0.82

0.0317

PF00970

Oxidoreductase FAD-binding domain

2 of 12

2.22

0.81

0.0317

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001199

Cytochrome b5-like heme/steroid binding domain

4 of 29

2.14

2.13

6.50e-05

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

4 of 30

2.13

2.12

6.50e-05

IPR018506

Cytochrome b5, heme-binding site

3 of 15

2.3

1.71

0.00060

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

2 of 3

2.83

1.32

0.0041

IPR015876

Acyl-CoA desaturase

2 of 2

3.0

1.32

0.0041

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

4 of 29

2.14

2.56

7.23e-06

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