STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HHT1_1Histone H3; Belongs to the histone H3 family. (136 aa)    
Predicted Functional Partners:
CU098_007150
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 
 
 0.998
CU098_012087
Uncharacterized protein.
    
 0.997
HIS2AV
Histone H2A; Belongs to the histone H2A family.
 
 
 0.991
DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.
   
 0.989
HAT1
Histone acetyltransferase 1.
    
 0.988
JHD1
JmjC domain-containing histone demethylation protein 1.
    
 0.986
CU098_012669
Uncharacterized protein.
    
 0.986
CU098_004270
Uncharacterized protein.
   
 0.985
CU098_010471
Bap31 domain-containing protein.
   
 0.985
RPB3
45 kDa subunit of RNA polymerase II.
   
 0.985
Your Current Organism:
Rhizopus stolonifer
NCBI taxonomy Id: 4846
Other names: Mucor stolonifer, R. stolonifer, Rhizopus nigricans
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.