GPA1_7 protein (Rhizopus stolonifer) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Score

GPA1_7

Guanine nucleotide-binding protein subunit alpha. (350 aa)

Predicted Functional Partners:

CU098_007090

0.829

GNB1_1

0.828

GPB1_1

0.828

GNB1_2

0.828

GPB1_2

0.828

RnGPB2

0.828

UCHL3_2

0.823

UCHL3_1

0.823

CU098_007174

0.772

CU098_001530

0.763

Your Current Organism:

Rhizopus stolonifer

NCBI taxonomy Id: 4846
Other names: Mucor stolonifer, R. stolonifer, Rhizopus nigricans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CU098_001530	GNB1_1	A0A367IJ07	A0A367IQQ8	Uncharacterized protein.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1.	0.806
CU098_001530	GNB1_2	A0A367IJ07	A0A367JGK5	Uncharacterized protein.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1.	0.806
CU098_001530	GPA1_7	A0A367IJ07	A0A367K8Z5	Uncharacterized protein.	Guanine nucleotide-binding protein subunit alpha.	0.763
CU098_001530	GPB1_1	A0A367IJ07	A0A367IZI7	Uncharacterized protein.	Guanine nucleotide-binding protein subunit beta 1.	0.806
CU098_001530	GPB1_2	A0A367IJ07	A0A367JTF4	Uncharacterized protein.	Guanine nucleotide-binding protein subunit beta 1.	0.806
CU098_001530	RnGPB2	A0A367IJ07	Q49S43	Uncharacterized protein.	Guanine nucleotide-binding protein subunit beta 1.	0.806
CU098_007090	GNB1_1	A0A367JVA8	A0A367IQQ8	G protein gamma domain-containing protein.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1.	0.979
CU098_007090	GNB1_2	A0A367JVA8	A0A367JGK5	G protein gamma domain-containing protein.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1.	0.979
CU098_007090	GPA1_7	A0A367JVA8	A0A367K8Z5	G protein gamma domain-containing protein.	Guanine nucleotide-binding protein subunit alpha.	0.829
CU098_007090	GPB1_1	A0A367JVA8	A0A367IZI7	G protein gamma domain-containing protein.	Guanine nucleotide-binding protein subunit beta 1.	0.979
CU098_007090	GPB1_2	A0A367JVA8	A0A367JTF4	G protein gamma domain-containing protein.	Guanine nucleotide-binding protein subunit beta 1.	0.979
CU098_007090	RnGPB2	A0A367JVA8	Q49S43	G protein gamma domain-containing protein.	Guanine nucleotide-binding protein subunit beta 1.	0.979
CU098_007174	GPA1_7	A0A367IZW7	A0A367K8Z5	Uncharacterized protein.	Guanine nucleotide-binding protein subunit alpha.	0.772
GNB1_1	CU098_001530	A0A367IQQ8	A0A367IJ07	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1.	Uncharacterized protein.	0.806
GNB1_1	CU098_007090	A0A367IQQ8	A0A367JVA8	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1.	G protein gamma domain-containing protein.	0.979
GNB1_1	GPA1_7	A0A367IQQ8	A0A367K8Z5	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1.	Guanine nucleotide-binding protein subunit alpha.	0.828
GNB1_2	CU098_001530	A0A367JGK5	A0A367IJ07	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1.	Uncharacterized protein.	0.806
GNB1_2	CU098_007090	A0A367JGK5	A0A367JVA8	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1.	G protein gamma domain-containing protein.	0.979
GNB1_2	GPA1_7	A0A367JGK5	A0A367K8Z5	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1.	Guanine nucleotide-binding protein subunit alpha.	0.828
GPA1_7	CU098_001530	A0A367K8Z5	A0A367IJ07	Guanine nucleotide-binding protein subunit alpha.	Uncharacterized protein.	0.763

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

29

PPI enrichment p-value:

8.27e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006487

Protein N-linked glycosylation

9 of 48

2.36

7.28

9.76e-17

GO:0018279

Protein N-linked glycosylation via asparagine

6 of 14

2.72

6.01

2.94e-12

GO:0043686

Co-translational protein modification

2 of 2

3.09

1.6

0.0013

GO:0018193

Peptidyl-amino acid modification

7 of 550

1.2

1.31

2.72e-05

GO:0006490

Oligosaccharide-lipid intermediate biosynthetic process

2 of 13

2.28

0.95

0.0179

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004579

Dolichyl-diphosphooligosaccharide-protein glycotransferase activity

2 of 2

3.09

1.14

0.0089

GO:0016758

Hexosyltransferase activity

4 of 138

1.55

0.96

0.0089

GO:0015095

Magnesium ion transmembrane transporter activity

2 of 13

2.28

0.82

0.0310

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008250

Oligosaccharyltransferase complex

7 of 11

2.9

7.93

7.80e-16

GO:0005789

Endoplasmic reticulum membrane

8 of 596

1.22

1.54

8.98e-07

GO:0005783

Endoplasmic reticulum

9 of 1011

1.04

1.2

8.98e-07

GO:0016021

Integral component of membrane

10 of 3298

0.57

0.47

0.00071

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11743

Oligosaccharyltransferase complex

8 of 10

2.99

9.55

7.08e-19

CL:11747

Oligosaccharyltransferase complex

5 of 5

3.09

5.84

1.70e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00510

N-Glycan biosynthesis

9 of 45

2.39

8.07

1.30e-18

map00513

Various types of N-glycan biosynthesis

7 of 46

2.27

5.74

2.87e-13

map04141

Protein processing in endoplasmic reticulum

7 of 230

1.57

2.64

9.02e-09

map01100

Metabolic pathways

9 of 2062

0.73

0.65

8.67e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5663205

Infectious disease

4 of 58

1.93

0.00010

MAP-446203

Asparagine N-linked glycosylation

6 of 272

1.44

1.59

4.81e-05

MAP-1643685

Disease

4 of 103

1.68

1.47

0.00063

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008250

Oligosaccharyltransferase complex

7 of 11

2.9

7.91

8.67e-16

GOCC:0005789

Endoplasmic reticulum membrane

8 of 209

1.67

3.17

4.13e-10

GOCC:0005783

Endoplasmic reticulum

8 of 413

1.38

2.05

4.24e-08

GOCC:0098827

Endoplasmic reticulum subcompartment

4 of 113

1.64

1.58

0.00026

GOCC:0016020

Membrane

9 of 2887

0.59

0.44

0.0038

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0256

Endoplasmic reticulum

4 of 46

2.03

2.34

1.57e-05

KW-0808

Transferase

8 of 1232

0.9

0.85

9.04e-05

KW-1133

Transmembrane helix

10 of 2737

0.65

0.57

0.00010

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003674

Oligosaccharyl transferase, STT3 subunit

2 of 2

3.09

0.96

0.0190

IPR021149

Oligosaccharyl transferase complex, subunit OST3/OST6

2 of 3

2.92

0.95

0.0190

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