STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DOT1Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (470 aa)    
Predicted Functional Partners:
HHT1_1
Histone H3; Belongs to the histone H3 family.
   
 0.989
HHT1_2
Histone H3.1.
   
 0.989
HIS71
Histone H3.3 type 1.
   
 0.957
CRP79
Poly(A) binding protein Crp79.
    
   0.945
CU098_007150
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 
 0.931
RPS27A_1
Ribosomal 40S subunit protein S27A.
    
   0.895
RPS27A_2
Ribosomal 40S subunit protein S27A.
    
   0.895
UBI::CRP6_1
Ubiquitin-40S ribosomal protein S27a.
    
   0.895
RPS27A_3
Ribosomal 40S subunit protein S27A.
    
   0.895
UBI::CRP6_2
Ubiquitin-40S ribosomal protein S27a.
    
   0.895
Your Current Organism:
Rhizopus stolonifer
NCBI taxonomy Id: 4846
Other names: Mucor stolonifer, R. stolonifer, Rhizopus nigricans
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.