node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SKA77225.1 | SKB01038.1 | SAMN02745166_00340 | SAMN02745166_03292 | Anthranilate synthase component 2. | Chorismate binding enzyme. | 0.999 |
SKA77225.1 | trpA | SAMN02745166_00340 | SAMN02745166_02643 | Anthranilate synthase component 2. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.974 |
SKA77225.1 | trpB | SAMN02745166_00340 | SAMN02745166_00030 | Anthranilate synthase component 2. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.968 |
SKA77225.1 | trpC | SAMN02745166_00340 | SAMN02745166_02894 | Anthranilate synthase component 2. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.998 |
SKA77225.1 | trpD | SAMN02745166_00340 | SAMN02745166_00954 | Anthranilate synthase component 2. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
SKA77225.1 | trpE | SAMN02745166_00340 | SAMN02745166_04490 | Anthranilate synthase component 2. | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.999 |
SKA77225.1 | trpF | SAMN02745166_00340 | SAMN02745166_04551 | Anthranilate synthase component 2. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.981 |
SKA88212.1 | glyA | SAMN02745166_01383 | SAMN02745166_01820 | Threonine dehydratase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.843 |
SKA88212.1 | trpA | SAMN02745166_01383 | SAMN02745166_02643 | Threonine dehydratase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.804 |
SKA88212.1 | trpB | SAMN02745166_01383 | SAMN02745166_00030 | Threonine dehydratase. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.853 |
SKA88212.1 | trpC | SAMN02745166_01383 | SAMN02745166_02894 | Threonine dehydratase. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.613 |
SKA88212.1 | trpF | SAMN02745166_01383 | SAMN02745166_04551 | Threonine dehydratase. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.574 |
SKB01038.1 | SKA77225.1 | SAMN02745166_03292 | SAMN02745166_00340 | Chorismate binding enzyme. | Anthranilate synthase component 2. | 0.999 |
SKB01038.1 | trpA | SAMN02745166_03292 | SAMN02745166_02643 | Chorismate binding enzyme. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.928 |
SKB01038.1 | trpB | SAMN02745166_03292 | SAMN02745166_00030 | Chorismate binding enzyme. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.899 |
SKB01038.1 | trpC | SAMN02745166_03292 | SAMN02745166_02894 | Chorismate binding enzyme. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.986 |
SKB01038.1 | trpD | SAMN02745166_03292 | SAMN02745166_00954 | Chorismate binding enzyme. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.998 |
SKB01038.1 | trpE | SAMN02745166_03292 | SAMN02745166_04490 | Chorismate binding enzyme. | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.757 |
SKB01038.1 | trpF | SAMN02745166_03292 | SAMN02745166_04551 | Chorismate binding enzyme. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.950 |
glyA | SKA88212.1 | SAMN02745166_01820 | SAMN02745166_01383 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine dehydratase. | 0.843 |