STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvDPFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; TIGRFAM: dihydroxy-acid dehydratase; HAMAP : Dihydroxy-acid dehydratase; KEGG: Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (550 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.992
leuA-2
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.976
UFO1_0621
TIGRFAM: branched-chain amino acid aminotransferase; KEGG: branched chain amino acid aminotransferase; PFAM: aminotransferase class IV.
  
 0.962
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.962
leuA
Transcriptional regulator with only HTH domain, AraC family; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
 
 
 0.952
UFO1_3589
PFAM: Glu/Leu/Phe/Val dehydrogenase, Glu/Leu/Phe/Val dehydrogenase dimerization region; KEGG: Glu/Leu/Phe/Val dehydrogenase; SMART: Glu/Leu/Phe/Val dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.919
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
    
 0.917
UFO1_3302
TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; KEGG: acetolactate synthase large subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein, thiamine pyrophosphate central domain-containing protein.
  
 0.893
UFO1_4274
TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; KEGG: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein, thiamine pyrophosphate central domain-containing protein.
  
 0.890
UFO1_4183
KEGG: ilvG, acetolactate synthase isozyme 2 large subunit IlvG; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein, thiamine pyrophosphate central domain-containing protein; Belongs to the TPP enzyme family.
  
 0.883
Your Current Organism:
Pelosinus sp. UFO1
NCBI taxonomy Id: 484770
Other names: P. sp. UFO1, Pelosinus lilaceae
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