OLF12062.1 protein (Actinophytocola xinjiangensis)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

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[Homology]

Score

OLF12062.1

LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)

Predicted Functional Partners:

OLF12063.1

0.953

OLF08762.1

0.770

OLF04454.1

0.754

OLF08515.1

0.733

OLF11540.1

0.698

OLF12061.1

0.588

OLF10510.1

0.571

OLF09414.1

0.571

OLF07635.1

0.571

OLF07414.1

0.571

Your Current Organism:

Actinophytocola xinjiangensis

NCBI taxonomy Id: 485602
Other names: A. xinjiangensis, Actinophytocola sp. QAIII60, Actinophytocola xinjiangensis Guo et al. 2011, Amycolatopsis sp. QAIII60, CGMCC 4.4663, DSM 45854, NBRC 106673, strain QAIII60

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OLF04454.1	OLF11540.1	BLA60_40870	BLA60_11320	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.610
OLF04454.1	OLF12062.1	BLA60_40870	BLA60_08540	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.754
OLF07414.1	OLF07635.1	BLA60_28055	BLA60_27385	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.541
OLF07414.1	OLF09414.1	BLA60_28055	BLA60_19795	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.442
OLF07414.1	OLF10510.1	BLA60_28055	BLA60_15085	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.437
OLF07414.1	OLF11540.1	BLA60_28055	BLA60_11320	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
OLF07414.1	OLF12061.1	BLA60_28055	BLA60_08535	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.571
OLF07414.1	OLF12062.1	BLA60_28055	BLA60_08540	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.571
OLF07635.1	OLF07414.1	BLA60_27385	BLA60_28055	Sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.541
OLF07635.1	OLF08762.1	BLA60_27385	BLA60_22395	Sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.522
OLF07635.1	OLF09414.1	BLA60_27385	BLA60_19795	Sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.553
OLF07635.1	OLF10510.1	BLA60_27385	BLA60_15085	Sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.561
OLF07635.1	OLF11540.1	BLA60_27385	BLA60_11320	Sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.987
OLF07635.1	OLF12061.1	BLA60_27385	BLA60_08535	Sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.821
OLF07635.1	OLF12062.1	BLA60_27385	BLA60_08540	Sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.571
OLF08515.1	OLF11540.1	BLA60_23390	BLA60_11320	ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.610
OLF08515.1	OLF12061.1	BLA60_23390	BLA60_08535	ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.459
OLF08515.1	OLF12062.1	BLA60_23390	BLA60_08540	ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.733
OLF08762.1	OLF07635.1	BLA60_22395	BLA60_27385	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.522
OLF08762.1	OLF11540.1	BLA60_22395	BLA60_11320	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.610

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003700

DNA-binding transcription factor activity

5 of 81

1.2

0.94

0.0035

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2296

UbiC transcription regulator-associated

3 of 5

2.19

1.65

0.0011

CL:1696

Duplicated hybrid motif, and Glucose permease domain IIB

3 of 12

1.81

1.29

0.0034

CL:1699

Glucose permease domain IIB

2 of 6

1.94

0.89

0.0256

CL:1685

Import into cell, and Hydrolase activity, hydrolyzing O-glycosyl compounds

4 of 120

0.94

0.53

0.0377

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0598

Phosphotransferase system

3 of 27

1.46

1.02

0.0066

KW-0805

Transcription regulation

5 of 96

1.13

0.91

0.0026

KW-0762

Sugar transport

3 of 35

1.35

0.89

0.0107

KW-0238

DNA-binding

5 of 146

0.95

0.69

0.0061

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00367

Phosphotransferase system, EIIB

3 of 12

1.81

1.18

0.0059

PF02378

Phosphotransferase system, EIIC

3 of 24

1.51

0.86

0.0186

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR028978

Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain superfamily

4 of 11

1.98

2.01

0.00013

IPR011663

UbiC transcription regulator-associated

4 of 11

1.98

2.01

0.00013

IPR000524

Transcription regulator HTH, GntR

4 of 14

1.87

1.94

0.00013

IPR036878

Glucose permease domain IIB

3 of 12

1.81

1.25

0.0042

IPR018113

Phosphotransferase system EIIB, cysteine phosphorylation site

3 of 12

1.81

1.25

0.0042

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00866

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to PUBMED:12757941. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.

4 of 11

1.98

2.46

1.19e-05

SM00345

Helix_turn_helix gluconate operon transcriptional repressor

4 of 14

1.87

2.34

1.33e-05

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