OLF09483.1 protein (Actinophytocola xinjiangensis)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

OLF09483.1

5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)

Predicted Functional Partners:

OLF05135.1

0.909

OLF12945.1

0.899

OLF09482.1

0.806

OLF09484.1

0.799

OLF14072.1

0.716

OLF14338.1

0.708

OLF04678.1

0.706

OLF09726.1

0.703

BLA60_38425

0.700

OLF13023.1

0.698

Your Current Organism:

Actinophytocola xinjiangensis

NCBI taxonomy Id: 485602
Other names: A. xinjiangensis, Actinophytocola sp. QAIII60, Actinophytocola xinjiangensis Guo et al. 2011, Amycolatopsis sp. QAIII60, CGMCC 4.4663, DSM 45854, NBRC 106673, strain QAIII60

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLA60_38425	OLF09483.1	BLA60_38425	BLA60_20215	Pentachlorophenol monooxygenase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology.	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.700
OLF04678.1	OLF09483.1	BLA60_39810	BLA60_20215	Coenzyme F420-0:L-glutamate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.706
OLF04678.1	OLF09726.1	BLA60_39810	BLA60_18255	Coenzyme F420-0:L-glutamate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.620
OLF04678.1	OLF13023.1	BLA60_39810	BLA60_07220	Coenzyme F420-0:L-glutamate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.729
OLF04678.1	OLF14072.1	BLA60_39810	BLA60_02595	Coenzyme F420-0:L-glutamate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.778
OLF04678.1	OLF14338.1	BLA60_39810	BLA60_04210	Coenzyme F420-0:L-glutamate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.583
OLF05135.1	OLF09483.1	BLA60_37795	BLA60_20215	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.909
OLF09482.1	OLF09483.1	BLA60_20210	BLA60_20215	MarR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.806
OLF09482.1	OLF09484.1	BLA60_20210	BLA60_20220	MarR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.628
OLF09483.1	BLA60_38425	BLA60_20215	BLA60_38425	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pentachlorophenol monooxygenase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.700
OLF09483.1	OLF04678.1	BLA60_20215	BLA60_39810	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Coenzyme F420-0:L-glutamate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.706
OLF09483.1	OLF05135.1	BLA60_20215	BLA60_37795	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.909
OLF09483.1	OLF09482.1	BLA60_20215	BLA60_20210	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	MarR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.806
OLF09483.1	OLF09484.1	BLA60_20215	BLA60_20220	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.799
OLF09483.1	OLF09726.1	BLA60_20215	BLA60_18255	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.703
OLF09483.1	OLF12945.1	BLA60_20215	BLA60_06750	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.899
OLF09483.1	OLF13023.1	BLA60_20215	BLA60_07220	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.698
OLF09483.1	OLF14072.1	BLA60_20215	BLA60_02595	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.716
OLF09483.1	OLF14338.1	BLA60_20215	BLA60_04210	5,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.708
OLF09484.1	OLF09482.1	BLA60_20220	BLA60_20210	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	MarR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.628

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.921

expected number of edges:

15

PPI enrichment p-value:

9.92e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006085

acetyl-CoA biosynthetic process

4 of 8

2.23

2.36

2.51e-05

GO:0019427

acetyl-CoA biosynthetic process from acetate

2 of 3

2.35

1.28

0.0042

GO:0022900

Electron transport chain

5 of 96

1.25

1.14

0.00052

GO:0006091

Generation of precursor metabolites and energy

6 of 184

1.04

0.93

0.00054

GO:0032787

Monocarboxylic acid metabolic process

4 of 113

1.08

0.72

0.0097

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030976

Thiamine pyrophosphate binding

4 of 8

2.23

2.49

1.32e-05

GO:0016208

AMP binding

2 of 3

2.35

1.15

0.0074

GO:0003987

acetate-CoA ligase activity

2 of 3

2.35

1.15

0.0074

GO:0043169

Cation binding

8 of 564

0.68

0.51

0.0037

GO:0036094

Small molecule binding

8 of 556

0.69

0.51

0.0037

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009274

Peptidoglycan-based cell wall

3 of 22

1.66

1.09

0.0055

GO:0005829

Cytosol

6 of 316

0.81

0.58

0.0065

GO:0005737

Cytoplasm

9 of 1132

0.43

0.31

0.0214

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1244

Citrate cycle (TCA cycle), and Propanoate metabolism

10 of 30

2.05

6.17

5.15e-17

CL:1245

Citrate cycle (TCA cycle)

6 of 23

1.95

3.42

1.14e-08

CL:1246

Citrate cycle (TCA cycle), and Novobiocin biosynthesis

5 of 14

2.08

3.23

1.40e-07

CL:1292

acetyl-CoA biosynthetic process

4 of 5

2.43

3.2

6.81e-07

CL:1248

Pyruvate ferredoxin/flavodoxin oxidoreductase, and Thiamine pyrophosphate enzyme, TPP-binding

4 of 7

2.29

2.96

1.52e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

daf00620

Pyruvate metabolism

11 of 38

1.99

6.53

6.02e-20

daf00650

Butanoate metabolism

5 of 14

2.08

3.58

1.76e-08

daf01200

Carbon metabolism

11 of 115

1.51

3.3

2.10e-15

daf00010

Glycolysis / Gluconeogenesis

7 of 46

1.71

3.24

6.14e-10

daf00020

Citrate cycle (TCA cycle)

5 of 22

1.89

3.03

8.64e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005618

Cell wall

3 of 12

1.93

1.34

0.0023

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0460

Magnesium

4 of 98

1.14

0.71

0.0154

KW-0479

Metal-binding

6 of 263

0.89

0.61

0.0093

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

4 of 7

2.29

2.62

7.79e-06

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

2 of 5

2.13

0.71

0.0481

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

2 of 5

2.13

0.71

0.0481

PF13193

AMP-binding enzyme C-terminal domain

2 of 7

1.99

0.7

0.0481

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

5 of 16

2.02

2.68

2.24e-06

IPR011766

Thiamine pyrophosphate enzyme, TPP-binding

4 of 7

2.29

2.58

9.79e-06

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