STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EFH90177.1DNA mismatch repair protein MutS domain protein; COGs: COG0249 Mismatch repair ATPase (MutS family); InterPro IPR000432:IPR007696; KEGG: bba:Bd2912 MutS-like mismatch repair protein, ATPase; PFAM: DNA mismatch repair protein MutS domain protein; SMART: DNA mismatch repair protein MutS domain protein; SPTR: A1ZV05 DNA mismatch repair protein MutS; PFAM: MutS domain V. (620 aa)    
Predicted Functional Partners:
mutL-2
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
 
 0.982
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
 
 0.980
Krac_8705
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.971
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 0.915
mutS2
MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
 
 
 0.860
Krac_0805
ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR019734:IPR013026:IPR014021:IPR001650:IPR 014016:IPR014017:IPR011990:IPR012337:IPR006055:IPR014001:I PR001440:IPR013520:IPR011545:IPR000212:IPR018329; KEGG: cbt:CLH_2071 ATP-dependent DNA helicase RecQ; PFAM: DEAD/DEAH box helicase domain protein; Exonuclease RNase T and DNA polymerase III; TPR repeat-containing protein; helicase domain protein; UvrD/REP helicase; SMART: helicase domain protein; DEAD-like helicase; Exonuclease; Tetratricopeptide repeat; SPTR: B2V462 ATP-dependent DNA helicase [...]
  
 0.818
Krac_9623
COGs: COG0258 5'-3' exonuclease (including N-terminal domain of PolI); InterProIPR020045:IPR020046:IPR020047:IPR002421:IPR 008918; KEGG: hoh:Hoch_5169 5'-3' exonuclease, SAM-fold domain protein; PFAM: 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; SPTR: D0LWK7 5'-3' exonuclease, SAM-fold domain protein; PFAM: 5'-3' exonuclease, C-terminal SAM fold; 5'-3' exonuclease, N-terminal resolvase-like domain.
   
 0.814
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
 
 0.627
EFH90178.1
phospholipase/Carboxylesterase; COGs: COG4099 peptidase; InterPro IPR003140; KEGG: gym:GYMC10_3191 phospholipase/carboxylesterase; PFAM: phospholipase/Carboxylesterase; SPTR: A6C3M0 Putative uncharacterized protein; PFAM: Dienelactone hydrolase family.
 
     0.517
Krac_3212
KEGG: nmr:Nmar_1413 hypothetical protein; SPTR: C7DG67 Putative uncharacterized protein.
    
 0.441
Your Current Organism:
Ktedonobacter racemifer
NCBI taxonomy Id: 485913
Other names: K. racemifer DSM 44963, Ktedonobacter racemifer DSM 44963, Ktedonobacter racemifer str. DSM 44963, Ktedonobacter racemifer strain DSM 44963
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