STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (514 aa)    
Predicted Functional Partners:
Krac_8705
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 
 0.992
recF
DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family.
 
  
 0.857
Krac_2411
Thioesterase; COGs: COG3319 Thioesterase domains of type I polyketide synthase or non-ribosomal peptide synthetase; InterPro IPR001031; KEGG: ara:Arad_7635 non-ribosomal peptide synthetase; PFAM: Thioesterase; SPTR: B4CW24 Amino acid adenylation domain protein; PFAM: Thioesterase domain.
  
  
 0.766
EFH90695.1
Hypothetical protein.
       0.762
Krac_6972
Amino acid adenylation domain protein; COGs: COG1020 Non-ribosomal peptide synthetase modules and related protein; InterProIPR010071:IPR009081:IPR006162:IPR020845:IPR 001242:IPR000873:IPR006163:IPR001031; KEGG: ava:Ava_1611 amino acid adenylation; PFAM: AMP-dependent synthetase and ligase; condensation domain protein; phosphopantetheine-binding; Thioesterase; SPTR: Q3MCQ2 Amino acid adenylation; TIGRFAM: amino acid adenylation domain protein; PFAM: Thioesterase domain; Phosphopantetheine attachment site; AMP-binding enzyme; Condensation domain; TIGRFAM: amino acid adenylation domain.
     
 0.757
EFH88919.1
Amino acid adenylation domain protein; COGs: COG1020 Non-ribosomal peptide synthetase modules and related protein; InterProIPR010071:IPR006162:IPR020845:IPR001242:IPR 000873:IPR006163:IPR009081:IPR020459; KEGG: npu:Npun_F2181 amino acid adenylation domain-containing protein; PFAM: AMP-dependent synthetase and ligase; condensation domain protein; phosphopantetheine-binding; SPTR: Q9RAH1 NosD; TIGRFAM: amino acid adenylation domain protein; PFAM: Phosphopantetheine attachment site; AMP-binding enzyme; Condensation domain; TIGRFAM: amino acid adenylation domain.
     
 0.736
Krac_7736
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
 
 
 
 0.732
EFH90505.1
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
 
 
 
 0.724
Krac_2693
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
 
 
 
 0.710
EFH90694.1
HAD-superfamily hydrolase, subfamily IIA; COGs: COG0647 sugar phosphatase of the HAD superfamily; InterPro IPR006357:IPR005834; KEGG: bcz:BCZK4685 4-nitrophenylphosphatase (p-nitrophenylphosphate phosphohydrolase); PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: Q2VP64 Putative uncharacterized protein C1_0025; TIGRFAM: HAD-superfamily hydrolase, subfamily IIA; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: HAD-superfamily subfamily IIA hydrolase, TIGR01457; haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Haloacid Dehalogena [...]
       0.691
Your Current Organism:
Ktedonobacter racemifer
NCBI taxonomy Id: 485913
Other names: K. racemifer DSM 44963, Ktedonobacter racemifer DSM 44963, Ktedonobacter racemifer str. DSM 44963, Ktedonobacter racemifer strain DSM 44963
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