STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa)    
Predicted Functional Partners:
Krac_7682
COGs: COG0112 Glycine/serine hydroxymethyltransferase; InterPro IPR015421:IPR001085:IPR015424; KEGG: sin:YN1551_1249 glycine hydroxymethyltransferase; PFAM: glycine hydroxymethyltransferase; PRIAM: Glycine hydroxymethyltransferase; SPTR: C3NEW0 Serine hydroxymethyltransferase; PFAM: Serine hydroxymethyltransferase.
  
 0.995
Krac_1335
Formiminotransferase-cyclodeaminase; COGs: COG3404 Methenyl tetrahydrofolate cyclohydrolase; InterPro IPR007044; KEGG: mca:MCA0507 methenyltetrahydrofolate cyclohydrolase; PFAM: Formiminotransferase-cyclodeaminase; SPTR: Q60BH0 Methenyltetrahydrofolate cyclohydrolase; PFAM: Formiminotransferase-cyclodeaminase.
    
 0.958
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 0.949
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.941
Krac_0413
COGs: COG0223 Methionyl-tRNA formyltransferase; InterPro IPR002376; KEGG: ttr:Tter_1161 formyl transferase domain protein; PFAM: formyl transferase domain protein; SPTR: D1CBA4 Formyl transferase domain protein; PFAM: Formyl transferase.
 
 
 0.939
xseA
Exodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family.
 
    0.939
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
 
 
 0.931
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
 
 
 0.925
Krac_8739
IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR013982; KEGG: cac:CAC2445 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; PFAM: AICARFT/IMPCHase bienzyme formylation region; PRIAM: IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme formylation region; SPTR: C5RI79 Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme.
 
 
 0.921
purN-2
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 
 0.903
Your Current Organism:
Ktedonobacter racemifer
NCBI taxonomy Id: 485913
Other names: K. racemifer DSM 44963, Ktedonobacter racemifer DSM 44963, Ktedonobacter racemifer str. DSM 44963, Ktedonobacter racemifer strain DSM 44963
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