Krac_5204 protein (Ktedonobacter racemifer) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Krac_5204

Response regulator receiver protein; InterPro IPR016032:IPR011991; KEGG: rrs:RoseRS_4161 two component transcriptional regulator; SPTR: A5V0V2 Two component transcriptional regulator, winged helix family. (114 aa)

Predicted Functional Partners:

Krac_5205

0.430

Krac_5206

0.430

Krac_5207

0.411

Your Current Organism:

Ktedonobacter racemifer

NCBI taxonomy Id: 485913
Other names: K. racemifer DSM 44963, Ktedonobacter racemifer DSM 44963, Ktedonobacter racemifer str. DSM 44963, Ktedonobacter racemifer strain DSM 44963

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
Krac_5204	Krac_5205	Response regulator receiver protein; InterPro IPR016032:IPR011991; KEGG: rrs:RoseRS_4161 two component transcriptional regulator; SPTR: A5V0V2 Two component transcriptional regulator, winged helix family.	KEGG: hypothetical protein; SPTR: A7TJN8 Putative uncharacterized protein.	0.430
Krac_5204	Krac_5206	Response regulator receiver protein; InterPro IPR016032:IPR011991; KEGG: rrs:RoseRS_4161 two component transcriptional regulator; SPTR: A5V0V2 Two component transcriptional regulator, winged helix family.	COGs: COG3451 Type IV secretory pathway VirB4 protein; KEGG: cai:Caci_4080 type IV secretory pathway VirB4 protein-like protein; SPTR: A5KS14 Type IV secretory pathway VirB4 components-like protein; PFAM: Domain of unknown function DUF87.	0.430
Krac_5204	Krac_5207	Response regulator receiver protein; InterPro IPR016032:IPR011991; KEGG: rrs:RoseRS_4161 two component transcriptional regulator; SPTR: A5V0V2 Two component transcriptional regulator, winged helix family.	KEGG: mjl:Mjls_3686 hypothetical protein; SPTR: Q1BFE0 Putative uncharacterized protein.	0.411
Krac_5205	Krac_5204	KEGG: hypothetical protein; SPTR: A7TJN8 Putative uncharacterized protein.	Response regulator receiver protein; InterPro IPR016032:IPR011991; KEGG: rrs:RoseRS_4161 two component transcriptional regulator; SPTR: A5V0V2 Two component transcriptional regulator, winged helix family.	0.430
Krac_5205	Krac_5206	KEGG: hypothetical protein; SPTR: A7TJN8 Putative uncharacterized protein.	COGs: COG3451 Type IV secretory pathway VirB4 protein; KEGG: cai:Caci_4080 type IV secretory pathway VirB4 protein-like protein; SPTR: A5KS14 Type IV secretory pathway VirB4 components-like protein; PFAM: Domain of unknown function DUF87.	0.773
Krac_5205	Krac_5207	KEGG: hypothetical protein; SPTR: A7TJN8 Putative uncharacterized protein.	KEGG: mjl:Mjls_3686 hypothetical protein; SPTR: Q1BFE0 Putative uncharacterized protein.	0.732
Krac_5206	Krac_5204	COGs: COG3451 Type IV secretory pathway VirB4 protein; KEGG: cai:Caci_4080 type IV secretory pathway VirB4 protein-like protein; SPTR: A5KS14 Type IV secretory pathway VirB4 components-like protein; PFAM: Domain of unknown function DUF87.	Response regulator receiver protein; InterPro IPR016032:IPR011991; KEGG: rrs:RoseRS_4161 two component transcriptional regulator; SPTR: A5V0V2 Two component transcriptional regulator, winged helix family.	0.430
Krac_5206	Krac_5205	COGs: COG3451 Type IV secretory pathway VirB4 protein; KEGG: cai:Caci_4080 type IV secretory pathway VirB4 protein-like protein; SPTR: A5KS14 Type IV secretory pathway VirB4 components-like protein; PFAM: Domain of unknown function DUF87.	KEGG: hypothetical protein; SPTR: A7TJN8 Putative uncharacterized protein.	0.773
Krac_5206	Krac_5207	COGs: COG3451 Type IV secretory pathway VirB4 protein; KEGG: cai:Caci_4080 type IV secretory pathway VirB4 protein-like protein; SPTR: A5KS14 Type IV secretory pathway VirB4 components-like protein; PFAM: Domain of unknown function DUF87.	KEGG: mjl:Mjls_3686 hypothetical protein; SPTR: Q1BFE0 Putative uncharacterized protein.	0.732
Krac_5207	Krac_5204	KEGG: mjl:Mjls_3686 hypothetical protein; SPTR: Q1BFE0 Putative uncharacterized protein.	Response regulator receiver protein; InterPro IPR016032:IPR011991; KEGG: rrs:RoseRS_4161 two component transcriptional regulator; SPTR: A5V0V2 Two component transcriptional regulator, winged helix family.	0.411
Krac_5207	Krac_5205	KEGG: mjl:Mjls_3686 hypothetical protein; SPTR: Q1BFE0 Putative uncharacterized protein.	KEGG: hypothetical protein; SPTR: A7TJN8 Putative uncharacterized protein.	0.732
Krac_5207	Krac_5206	KEGG: mjl:Mjls_3686 hypothetical protein; SPTR: Q1BFE0 Putative uncharacterized protein.	COGs: COG3451 Type IV secretory pathway VirB4 protein; KEGG: cai:Caci_4080 type IV secretory pathway VirB4 protein-like protein; SPTR: A5KS14 Type IV secretory pathway VirB4 components-like protein; PFAM: Domain of unknown function DUF87.	0.732

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.871

expected number of edges:

11

PPI enrichment p-value:

1.92e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007154

Cell communication

11 of 1248

1.21

1.82

2.40e-10

GO:0006468

Protein phosphorylation

6 of 426

1.41

1.63

2.20e-05

GO:0048312

Intracellular distribution of mitochondria

2 of 4

2.96

1.63

0.0011

GO:1900242

Regulation of synaptic vesicle endocytosis

2 of 5

2.87

1.57

0.0014

GO:0007165

Signal transduction

9 of 1111

1.17

1.5

2.71e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001784

Phosphotyrosine residue binding

3 of 20

2.44

2.2

7.26e-05

GO:0005102

Signaling receptor binding

5 of 184

1.7

1.87

5.16e-05

GO:0030971

Receptor tyrosine kinase binding

2 of 7

2.72

1.72

0.00072

GO:0004672

Protein kinase activity

6 of 411

1.43

1.57

5.16e-05

GO:0004713

Protein tyrosine kinase activity

3 of 97

1.75

1.41

0.0011

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043195

Terminal bouton

2 of 23

2.2

0.95

0.0174

GO:0044297

Cell body

2 of 26

2.15

0.94

0.0174

GO:0031234

Extrinsic component of cytoplasmic side of plasma membrane

2 of 37

2.0

0.93

0.0174

GO:0005925

Focal adhesion

2 of 34

2.03

0.93

0.0174

GO:0030425

Dendrite

3 of 108

1.71

0.88

0.0174

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:257

Mixed, incl. RHO GTPase cycle, and Non-membrane spanning protein tyrosine kinase activity

5 of 127

1.86

2.26

1.12e-05

CL:532

Interleukin-15 signaling, and Signalling to RAS

2 of 5

2.87

1.21

0.0064

CL:450

MAP2K and MAPK activation

2 of 6

2.79

1.21

0.0064

CL:344

Intracellular distribution of mitochondria, and Immunoglobulin V-set domain

2 of 5

2.87

1.21

0.0064

CL:1715

Mixed, incl. Localization of the PINCH-ILK-PARVIN complex to focal adhesions, and Dedicator of cytokinesis, C-terminal, lobe A

2 of 5

2.87

1.21

0.0064

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04068

FoxO signaling pathway

3 of 100

1.74

1.22

0.0031

map04150

mTOR signaling pathway

3 of 128

1.63

1.17

0.0032

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-187687

Signalling to ERKs

4 of 8

2.96

4.1

2.80e-08

MAP-167044

Signalling to RAS

3 of 4

3.14

3.27

1.15e-06

MAP-187037

Signaling by NTRK1 (TRKA)

4 of 35

2.32

3.03

1.15e-06

MAP-166520

Signaling by NTRKs

4 of 42

2.24

2.93

1.52e-06

MAP-9006934

Signaling by Receptor Tyrosine Kinases

6 of 220

1.7

2.54

3.22e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045121

Membrane raft

3 of 18

2.49

2.04

0.00016

GOCC:0032473

Cytoplasmic side of mitochondrial outer membrane

2 of 2

3.26

1.81

0.00055

GOCC:0005901

Caveola

2 of 10

2.56

1.28

0.0045

GOCC:0005925

Focal adhesion

2 of 16

2.36

1.17

0.0070

GOCC:0110165

Cellular anatomical entity

11 of 8823

0.36

0.28

0.0138

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0727

SH2 domain

2 of 32

2.06

1.03

0.0115

KW-0418

Kinase

3 of 123

1.65

1.0

0.0087

KW-0547

Nucleotide-binding

4 of 462

1.2

0.8

0.0093

KW-0723

Serine/threonine-protein kinase

2 of 73

1.7

0.74

0.0355

KW-0067

ATP-binding

3 of 341

1.21

0.63

0.0355

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036860

SH2 domain superfamily

4 of 36

2.31

2.53

1.32e-05

IPR017441

Protein kinase, ATP binding site

4 of 90

1.91

1.81

0.00019

IPR000719

Protein kinase domain

5 of 246

1.57

1.56

0.00019

IPR011009

Protein kinase-like domain superfamily

5 of 287

1.5

0.00020

IPR001245

Serine-threonine/tyrosine-protein kinase, catalytic domain

3 of 56

1.99

1.35

0.0023

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00252

Src homology 2 domains

3 of 32

2.24

1.84

0.00031

SM00219

Tyrosine kinase, catalytic domain

2 of 6

2.79

1.55

0.0015

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