STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
menCO-succinylbenzoic acid (OSB) synthetase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (381 aa)    
Predicted Functional Partners:
menD
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylic acid synthase/2-oxoglutarate decarboxylase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily.
  
 0.912
menE
O-succinylbenzoate-CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA); Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
 
 
  0.908
menH
Alpha/beta hydrolase fold protein; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
 
  
  0.806
Krac_3867
Mandelate racemase/muconate lactonizing protein; COGs: COG4948 L-alanine-DL-glutamate epimerase; InterPro IPR013341:IPR013342; KEGG: sma:SAV_1408 racemase; PFAM: Mandelate racemase/muconate lactonizing protein; SPTR: Q82N95 Putative racemase; PFAM: Mandelate racemase / muconate lactonizing enzyme, C-terminal domain; Mandelate racemase / muconate lactonizing enzyme, N-terminal domain.
  
     0.763
menB
Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA).
 
   
 0.724
EFH90118.1
COGs: COG3321 Polyketide synthase modules and related protein; InterProIPR016038:IPR001227:IPR000873:IPR006163:IPR 014030:IPR014031:IPR014043:IPR016039:IPR016035:IPR009081:I PR016036:IPR006162:IPR020845:IPR018201; KEGG: ava:Ava_4108 beta-ketoacyl synthase; PFAM: Beta-ketoacyl synthase; AMP-dependent synthetase and ligase; phosphopantetheine-binding; Acyl transferase; SPTR: Q3M5M8 Beta-ketoacyl synthase; PFAM: Acyl transferase domain; Phosphopantetheine attachment site; Beta-ketoacyl synthase, N-terminal domain; AMP-binding enzyme; Beta-ketoacyl synthase, C-terminal domain.
  
 
 0.687
Krac_8112
COGs: COG1169 Isochorismate synthase; InterPro IPR015890:IPR005801:IPR004561:IPR019999; KEGG: chl:Chy400_3941 isochorismate synthase; PFAM: Chorismate binding-like; SPTR: B9LF87 Isochorismate synthase; TIGRFAM: isochorismate synthase; PFAM: chorismate binding enzyme; TIGRFAM: isochorismate synthases.
   
 0.589
Krac_4073
COGs: COG1169 Isochorismate synthase; InterPro IPR004561:IPR015890:IPR005801; KEGG: dds:Ddes_1345 isochorismate synthase; PFAM: Chorismate binding-like; SPTR: B8J0H0 Isochorismate synthase; TIGRFAM: isochorismate synthase; PFAM: chorismate binding enzyme; TIGRFAM: isochorismate synthases.
   
 0.510
Krac_8118
Response regulator receiver protein; InterPro IPR011006; KEGG: rme:Rmet_4829 two component transcriptional regulator; SPTR: A3J8E9 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
       0.439
Your Current Organism:
Ktedonobacter racemifer
NCBI taxonomy Id: 485913
Other names: K. racemifer DSM 44963, Ktedonobacter racemifer DSM 44963, Ktedonobacter racemifer str. DSM 44963, Ktedonobacter racemifer strain DSM 44963
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.