STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (212 aa)    
Predicted Functional Partners:
Dret_1064
KEGG: dma:DMR_23180 exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase.
 
 0.996
rnfE
RnfA-Nqr electron transport subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
 
  
 0.865
nfo
Apurinic endonuclease Apn1; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
  
 
 0.749
Dret_2404
DNA polymerase I; KEGG: dvm:DvMF_1713 DNA polymerase I; TIGRFAM: DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: DNA-directed DNA polymerase; Helix-hairpin- helix domain protein class 2; 5'-3' exonuclease.
  
 
 0.685
Dret_0254
KEGG: dma:DMR_16970 formamidopyrimidine-DNA glycosylase; TIGRFAM: formamidopyrimidine-DNA glycosylase; PFAM: Formamidopyrimidine-DNA glycosylase catalytic domain protein; zinc finger Fpg domain protein; DNA glycosylase/AP lyase, H2TH DNA-binding.
   
  
 0.612
rnfB
Electron transport complex, RnfABCDGE type, B subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
  
  
 0.560
Dret_0827
KEGG: dvm:DvMF_1980 hypothetical protein.
       0.534
rnfG
Electron transport complex, RnfABCDGE type, G subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.
  
  
 0.533
Dret_0579
PFAM: OmpA/MotB domain protein; KEGG: pca:Pcar_1171 MotB-like flagellar protein.
    
   0.487
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 
 0.468
Your Current Organism:
Desulfohalobium retbaense
NCBI taxonomy Id: 485915
Other names: D. retbaense DSM 5692, Desulfohalobium retbaense DSM 5692, Desulfohalobium retbaense str. DSM 5692, Desulfohalobium retbaense strain DSM 5692
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