node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dret_0108 | secD | Dret_0108 | Dret_0846 | PFAM: acriflavin resistance protein; KEGG: pca:Pcar_0669 AcrB/AcrD/AcrF family cation efflux protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.437 |
Dret_0108 | secF | Dret_0108 | Dret_0847 | PFAM: acriflavin resistance protein; KEGG: pca:Pcar_0669 AcrB/AcrD/AcrF family cation efflux protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.470 |
Dret_0108 | yajC | Dret_0108 | Dret_0845 | PFAM: acriflavin resistance protein; KEGG: pca:Pcar_0669 AcrB/AcrD/AcrF family cation efflux protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.469 |
Dret_1548 | Dret_2249 | Dret_1548 | Dret_2249 | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | KEGG: dma:DMR_39450 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: Peptidase S24, S26A and S26B, conserved region; Belongs to the peptidase S26 family. | 0.661 |
Dret_1548 | secD | Dret_1548 | Dret_0846 | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.829 |
Dret_1548 | secE | Dret_1548 | Dret_2078 | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.996 |
Dret_1548 | secF | Dret_1548 | Dret_0847 | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.687 |
Dret_1548 | secY | Dret_1548 | Dret_2045 | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.993 |
Dret_1548 | yajC | Dret_1548 | Dret_0845 | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.933 |
Dret_1548 | yidC | Dret_1548 | Dret_2139 | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Membrane protein insertase, YidC/Oxa1 family; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.983 |
Dret_2249 | Dret_1548 | Dret_2249 | Dret_1548 | KEGG: dma:DMR_39450 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: Peptidase S24, S26A and S26B, conserved region; Belongs to the peptidase S26 family. | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.661 |
Dret_2249 | secD | Dret_2249 | Dret_0846 | KEGG: dma:DMR_39450 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: Peptidase S24, S26A and S26B, conserved region; Belongs to the peptidase S26 family. | Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.643 |
Dret_2249 | secE | Dret_2249 | Dret_2078 | KEGG: dma:DMR_39450 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: Peptidase S24, S26A and S26B, conserved region; Belongs to the peptidase S26 family. | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.484 |
Dret_2249 | secF | Dret_2249 | Dret_0847 | KEGG: dma:DMR_39450 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: Peptidase S24, S26A and S26B, conserved region; Belongs to the peptidase S26 family. | Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.608 |
Dret_2249 | secY | Dret_2249 | Dret_2045 | KEGG: dma:DMR_39450 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: Peptidase S24, S26A and S26B, conserved region; Belongs to the peptidase S26 family. | Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.675 |
Dret_2249 | tatC | Dret_2249 | Dret_0991 | KEGG: dma:DMR_39450 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: Peptidase S24, S26A and S26B, conserved region; Belongs to the peptidase S26 family. | Sec-independent protein translocase, TatC subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.537 |
Dret_2249 | topA | Dret_2249 | Dret_0083 | KEGG: dma:DMR_39450 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: Peptidase S24, S26A and S26B, conserved region; Belongs to the peptidase S26 family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.565 |
Dret_2249 | yajC | Dret_2249 | Dret_0845 | KEGG: dma:DMR_39450 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: Peptidase S24, S26A and S26B, conserved region; Belongs to the peptidase S26 family. | Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.532 |
Dret_2249 | yidC | Dret_2249 | Dret_2139 | KEGG: dma:DMR_39450 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: Peptidase S24, S26A and S26B, conserved region; Belongs to the peptidase S26 family. | Membrane protein insertase, YidC/Oxa1 family; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.706 |
secD | Dret_0108 | Dret_0846 | Dret_0108 | Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | PFAM: acriflavin resistance protein; KEGG: pca:Pcar_0669 AcrB/AcrD/AcrF family cation efflux protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.437 |