node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dret_0264 | Dret_0830 | Dret_0264 | Dret_0830 | KEGG: dma:DMR_33050 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD- superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD- superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | TIGRFAM: cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Cysteinyl-tRNA synthetase class Ia; KEGG: dma:DMR_30710 cysteine synthase B. | 0.945 |
Dret_0264 | Dret_2251 | Dret_0264 | Dret_2251 | KEGG: dma:DMR_33050 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD- superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD- superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: dvm:DvMF_0011 serine dehydratase alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.943 |
Dret_0264 | glyA | Dret_0264 | Dret_1418 | KEGG: dma:DMR_33050 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD- superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD- superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.954 |
Dret_0830 | Dret_0264 | Dret_0830 | Dret_0264 | TIGRFAM: cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Cysteinyl-tRNA synthetase class Ia; KEGG: dma:DMR_30710 cysteine synthase B. | KEGG: dma:DMR_33050 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD- superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD- superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | 0.945 |
Dret_0830 | Dret_2251 | Dret_0830 | Dret_2251 | TIGRFAM: cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Cysteinyl-tRNA synthetase class Ia; KEGG: dma:DMR_30710 cysteine synthase B. | PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: dvm:DvMF_0011 serine dehydratase alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.917 |
Dret_0830 | folD | Dret_0830 | Dret_0218 | TIGRFAM: cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Cysteinyl-tRNA synthetase class Ia; KEGG: dma:DMR_30710 cysteine synthase B. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.529 |
Dret_0830 | glyA | Dret_0830 | Dret_1418 | TIGRFAM: cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Cysteinyl-tRNA synthetase class Ia; KEGG: dma:DMR_30710 cysteine synthase B. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
Dret_1559 | Dret_1579 | Dret_1559 | Dret_1579 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dvu:DVU1684 glycine cleavage system T protein. | KEGG: dvm:DvMF_0223 glycine dehydrogenase subunit 2. | 0.999 |
Dret_1559 | Dret_2251 | Dret_1559 | Dret_2251 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dvu:DVU1684 glycine cleavage system T protein. | PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: dvm:DvMF_0011 serine dehydratase alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.412 |
Dret_1559 | Dret_2286 | Dret_1559 | Dret_2286 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dvu:DVU1684 glycine cleavage system T protein. | IMP cyclohydrolase; KEGG: dde:Dde_0174 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; SMART: AICARFT/IMPCHase bienzyme formylation region. | 0.922 |
Dret_1559 | folD | Dret_1559 | Dret_0218 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dvu:DVU1684 glycine cleavage system T protein. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.955 |
Dret_1559 | gcvH | Dret_1559 | Dret_1577 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dvu:DVU1684 glycine cleavage system T protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
Dret_1559 | gcvPA | Dret_1559 | Dret_1578 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dvu:DVU1684 glycine cleavage system T protein. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
Dret_1559 | glyA | Dret_1559 | Dret_1418 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dvu:DVU1684 glycine cleavage system T protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
Dret_1559 | purN | Dret_1559 | Dret_0253 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dvu:DVU1684 glycine cleavage system T protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.926 |
Dret_1579 | Dret_1559 | Dret_1579 | Dret_1559 | KEGG: dvm:DvMF_0223 glycine dehydrogenase subunit 2. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dvu:DVU1684 glycine cleavage system T protein. | 0.999 |
Dret_1579 | folD | Dret_1579 | Dret_0218 | KEGG: dvm:DvMF_0223 glycine dehydrogenase subunit 2. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.606 |
Dret_1579 | gcvH | Dret_1579 | Dret_1577 | KEGG: dvm:DvMF_0223 glycine dehydrogenase subunit 2. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
Dret_1579 | gcvPA | Dret_1579 | Dret_1578 | KEGG: dvm:DvMF_0223 glycine dehydrogenase subunit 2. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
Dret_1579 | glyA | Dret_1579 | Dret_1418 | KEGG: dvm:DvMF_0223 glycine dehydrogenase subunit 2. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.980 |