STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Dtox_1328PFAM: pentapeptide repeat protein; KEGG: rce:RC1_0668 pentapeptide repeat family protein. (929 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.766
Dtox_1327
PFAM: Radical SAM domain protein; KEGG: dat:HRM2_06230 hypothetical protein.
       0.605
Dtox_1329
PFAM: NHL repeat containing protein; KEGG: pna:Pnap_4087 hypothetical protein.
       0.536
Dtox_4319
KEGG: rde:RD1_3736 hypothetical protein.
  
 
 0.519
Dtox_3974
PFAM: ErfK/YbiS/YcfS/YnhG family protein; Peptidoglycan-binding LysM; SMART: Peptidoglycan-binding LysM; KEGG: afr:AFE_0569 ErfK/YbiS/YcfS/YnhG family.
   
 
 0.515
Dtox_1576
KEGG: sse:Ssed_2865 signal transduction histidine kinase-like protein; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; PAS fold-3 domain protein; Hpt domain protein; Cache domain protein; PAS fold domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; PAC repeat-containing protein; PAS domain-containing protein; histidine kinase HAMP region domain protein.
 
 
 0.510
Dtox_2674
TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; Methyltransferase type 12; Non-ribosomal peptide synthetase; condensation domain protein; KEGG: pfl:PFL_3492 pyochelin synthetase F.
 
   
 0.507
msrB
methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
     
 0.505
Dtox_1326
KEGG: plu:plu3558 hypothetical protein.
 
     0.460
Dtox_2677
PFAM: 4'-phosphopantetheinyl transferase; KEGG: mes:Meso_2583 4'-phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily.
  
     0.448
Your Current Organism:
Desulfofarcimen acetoxidans
NCBI taxonomy Id: 485916
Other names: D. acetoxidans DSM 771, Desulfofarcimen acetoxidans DSM 771, Desulfotomaculum acetoxidans DSM 771
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