STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
spoIIABAnti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (146 aa)    
Predicted Functional Partners:
Dtox_2064
TIGRFAM: anti-sigma F factor antagonist; anti-anti- sigma factor; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; KEGG: bsu:BSU23470 anti-anti-sigma factor (antagonist of SpoIIAB); Belongs to the anti-sigma-factor antagonist family.
 
 
 0.995
Dtox_2066
RNA polymerase, sigma 28 subunit, SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
 
 0.989
Dtox_1555
KEGG: met:M446_6441 GAF sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; Hpt domain protein; PAS fold- 4 domain protein; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; PAS domain-containing protein.
 
  
 0.879
Dtox_1576
KEGG: sse:Ssed_2865 signal transduction histidine kinase-like protein; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; PAS fold-3 domain protein; Hpt domain protein; Cache domain protein; PAS fold domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; PAC repeat-containing protein; PAS domain-containing protein; histidine kinase HAMP region domain protein.
 
  
 0.856
Dtox_1067
RNA polymerase, sigma 28 subunit, SigG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.851
Dtox_2111
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
  
 0.849
Dtox_1244
TIGRFAM: transcriptional regulator, AbrB family; PFAM: SpoVT/AbrB domain protein; KEGG: baa:BA_0642 hypothetical protein predicted by GeneMark.
  
   
 0.839
Dtox_0216
TIGRFAM: stage V sporulation protein T; transcriptional regulator, AbrB family; PFAM: SpoVT/AbrB domain protein; KEGG: baa:BA_0642 hypothetical protein predicted by GeneMark.
  
   
 0.831
Dtox_0227
KEGG: bar:GBAA0061 stage II sporulation protein E; TIGRFAM: stage II sporulation protein E; PFAM: Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein.
  
  
 0.828
Dtox_1065
sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family.
  
  
 0.822
Your Current Organism:
Desulfofarcimen acetoxidans
NCBI taxonomy Id: 485916
Other names: D. acetoxidans DSM 771, Desulfofarcimen acetoxidans DSM 771, Desulfotomaculum acetoxidans DSM 771
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