node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cpin_3070 | Cpin_4299 | Cpin_3070 | Cpin_4299 | KEGG: gur:Gura_3277 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; Belongs to the folylpolyglutamate synthase family. | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | 0.546 |
Cpin_3070 | thyA | Cpin_3070 | Cpin_6453 | KEGG: gur:Gura_3277 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.840 |
Cpin_4298 | Cpin_4299 | Cpin_4298 | Cpin_4299 | Hypothetical protein. | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | 0.506 |
Cpin_4299 | Cpin_3070 | Cpin_4299 | Cpin_3070 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | KEGG: gur:Gura_3277 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; Belongs to the folylpolyglutamate synthase family. | 0.546 |
Cpin_4299 | Cpin_4298 | Cpin_4299 | Cpin_4298 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | Hypothetical protein. | 0.506 |
Cpin_4299 | Cpin_4300 | Cpin_4299 | Cpin_4300 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | KEGG: jan:Jann_4029 hypothetical protein. | 0.584 |
Cpin_4299 | Cpin_5547 | Cpin_4299 | Cpin_5547 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | PFAM: 3-demethylubiquinone-9 3-methyltransferase; KEGG: rfr:Rfer_4108 3-demethylubiquinone-9 3- methyltransferase. | 0.416 |
Cpin_4299 | gcvH | Cpin_4299 | Cpin_0436 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.546 |
Cpin_4299 | gcvP | Cpin_4299 | Cpin_1950 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.595 |
Cpin_4299 | gcvT | Cpin_4299 | Cpin_0599 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.549 |
Cpin_4299 | thyA | Cpin_4299 | Cpin_6453 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.832 |
Cpin_4300 | Cpin_4299 | Cpin_4300 | Cpin_4299 | KEGG: jan:Jann_4029 hypothetical protein. | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | 0.584 |
Cpin_5547 | Cpin_4299 | Cpin_5547 | Cpin_4299 | PFAM: 3-demethylubiquinone-9 3-methyltransferase; KEGG: rfr:Rfer_4108 3-demethylubiquinone-9 3- methyltransferase. | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | 0.416 |
gcvH | Cpin_4299 | Cpin_0436 | Cpin_4299 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | 0.546 |
gcvH | gcvP | Cpin_0436 | Cpin_1950 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT | Cpin_0436 | Cpin_0599 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH | thyA | Cpin_0436 | Cpin_6453 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.604 |
gcvP | Cpin_4299 | Cpin_1950 | Cpin_4299 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | PFAM: bifunctional deaminase-reductase domain protein; KEGG: abc:ACICU_01927 dihydrofolate reductase. | 0.595 |
gcvP | gcvH | Cpin_1950 | Cpin_0436 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
gcvP | gcvT | Cpin_1950 | Cpin_0599 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |