Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
nlaXMDNA (cytosine-5-)-methyltransferase; This methylase recognizes the double-stranded sequence CCNGG, causes specific methylation on C-2 on both strands; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (313 aa)    
Predicted Functional Partners:
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
     
  0.900
mtnN
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
     
  0.900
ARB03749.1
Restriction endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.773
Vsr
Very short patch repair endonuclease; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination.
      0.752
nlaIIIM
Modification methylase; This methylase recognizes the double-stranded sequence CATG, causes specific methylation on A-2 on both strands and protects the DNA from cleavage by the NlaIII endonuclease; Belongs to the N(4)/N(6)-methyltransferase family.
       0.572
nlaIIIR
Restriction endonuclease; Recognizes the double-stranded sequence CATG and cleaves after G-4.
       0.572
ARB04770.1
HNH endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.533
ARB05538.1
DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
      0.487
vapC
VapC toxin family PIN domain ribonuclease; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.
      
 0.469
Your Current Organism:
Neisseria lactamica
NCBI taxonomy Id: 486
Other names: ATCC 23970, CCUG 5853, CIP 72.17, DSM 4691, N. lactamica, NCTC 10617, Neisseria lactamicus
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