Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ohrRHomoprotocatechuate degradation operon regulator, HpaR; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)    
Predicted Functional Partners:
oxyR
LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family.
   
  
 0.769
cysB
LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.546
hslO
Molecular chaperone Hsp33; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
      
 0.537
ARB04166.1
4-hydroxyphenylacetate 3-monooxygenase, reductase component; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.530
ARB04220.1
EamA family transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.525
bcp
Peroxiredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.504
ARB04167.1
Mannose-1-phosphate guanylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.478
ARB05147.1
AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.474
ARB04864.1
Autotransporter outer membrane beta-barrel domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.462
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.454
Your Current Organism:
Neisseria lactamica
NCBI taxonomy Id: 486
Other names: ATCC 23970, CCUG 5853, CIP 72.17, DSM 4691, N. lactamica, NCTC 10617, Neisseria lactamicus
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