B0CU11_LACBS protein (Laccaria bicolor) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

B0CU11_LACBS

Predicted protein; Belongs to the peptidase C19 family. (1273 aa)

Predicted Functional Partners:

B0CSP4_LACBS

0.787

B0CYT8_LACBS

0.772

B0CPN7_LACBS

0.769

B0CPD9_LACBS

0.761

B0CSS1_LACBS

0.757

B0D0D6_LACBS

0.756

B0CV98_LACBS

0.748

B0CSV0_LACBS

0.747

B0CZG0_LACBS

0.742

B0CPS1_LACBS

0.739

Your Current Organism:

Laccaria bicolor

NCBI taxonomy Id: 486041
Other names: L. bicolor S238N-H82, Laccaria bicolor S238N-H82

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0CPD9_LACBS	B0CPN7_LACBS	B0CPD9	B0CPN7	Predicted protein.	Predicted protein.	0.995
B0CPD9_LACBS	B0CPS1_LACBS	B0CPD9	B0CPS1	Predicted protein.	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	0.999
B0CPD9_LACBS	B0CSP4_LACBS	B0CPD9	B0CSP4	Predicted protein.	Predicted protein; Belongs to the universal ribosomal protein uL3 family.	0.997
B0CPD9_LACBS	B0CSV0_LACBS	B0CPD9	B0CSV0	Predicted protein.	Predicted protein.	0.999
B0CPD9_LACBS	B0CU11_LACBS	B0CPD9	B0CU11	Predicted protein.	Predicted protein; Belongs to the peptidase C19 family.	0.761
B0CPD9_LACBS	B0CV98_LACBS	B0CPD9	B0CV98	Predicted protein.	Predicted protein; Belongs to the universal ribosomal protein uL6 family.	0.990
B0CPD9_LACBS	B0CYT8_LACBS	B0CPD9	B0CYT8	Predicted protein.	Predicted protein.	0.999
B0CPD9_LACBS	B0CZG0_LACBS	B0CPD9	B0CZG0	Predicted protein.	Predicted protein.	0.998
B0CPD9_LACBS	B0D0D6_LACBS	B0CPD9	B0D0D6	Predicted protein.	Predicted protein; Belongs to the universal ribosomal protein uS5 family.	0.993
B0CPN7_LACBS	B0CPD9_LACBS	B0CPN7	B0CPD9	Predicted protein.	Predicted protein.	0.995
B0CPN7_LACBS	B0CPS1_LACBS	B0CPN7	B0CPS1	Predicted protein.	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	0.995
B0CPN7_LACBS	B0CSP4_LACBS	B0CPN7	B0CSP4	Predicted protein.	Predicted protein; Belongs to the universal ribosomal protein uL3 family.	0.994
B0CPN7_LACBS	B0CSV0_LACBS	B0CPN7	B0CSV0	Predicted protein.	Predicted protein.	0.955
B0CPN7_LACBS	B0CU11_LACBS	B0CPN7	B0CU11	Predicted protein.	Predicted protein; Belongs to the peptidase C19 family.	0.769
B0CPN7_LACBS	B0CV98_LACBS	B0CPN7	B0CV98	Predicted protein.	Predicted protein; Belongs to the universal ribosomal protein uL6 family.	0.993
B0CPN7_LACBS	B0CYT8_LACBS	B0CPN7	B0CYT8	Predicted protein.	Predicted protein.	0.995
B0CPN7_LACBS	B0CZG0_LACBS	B0CPN7	B0CZG0	Predicted protein.	Predicted protein.	0.996
B0CPN7_LACBS	B0D0D6_LACBS	B0CPN7	B0D0D6	Predicted protein.	Predicted protein; Belongs to the universal ribosomal protein uS5 family.	0.954
B0CPS1_LACBS	B0CPD9_LACBS	B0CPS1	B0CPD9	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Predicted protein.	0.999
B0CPS1_LACBS	B0CPN7_LACBS	B0CPS1	B0CPN7	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Predicted protein.	0.995

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.876

expected number of edges:

13

PPI enrichment p-value:

5.1e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

8 of 722

0.69

0.52

0.0033

GO:0016021

Integral component of membrane

8 of 1042

0.53

0.37

0.0168

GO:0016020

Membrane

9 of 1458

0.44

0.32

0.0168

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4236

Diguanylate cyclase

6 of 38

1.85

3.03

5.65e-08

CL:4239

EAL domain, and PAS-associated, C-terminal

5 of 33

1.83

2.56

1.23e-06

CL:4058

Phosphorelay signal transduction system, and Nucleotide cyclase

9 of 144

1.45

2.43

1.19e-09

CL:4243

EAL domain, and Target SNARE coiled-coil homology domain

4 of 19

1.97

2.32

1.38e-05

CL:4245

EAL domain, and Target SNARE coiled-coil homology domain

3 of 12

2.05

1.73

0.00039

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029787

Nucleotide cyclase

6 of 61

1.64

2.15

4.06e-06

IPR000160

GGDEF domain

6 of 62

1.64

2.14

4.06e-06

IPR043128

Reverse transcriptase/Diguanylate cyclase domain

6 of 65

1.61

2.11

4.06e-06

IPR001633

EAL domain

4 of 30

1.77

1.66

0.00028

IPR035919

EAL domain superfamily

4 of 31

1.76

1.65

0.00028

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00267

Diguanylate cyclase

6 of 57

1.67

2.54

2.13e-07

SM00052

Putative diguanylate phosphodiesterase

4 of 30

1.77

1.97

4.24e-05

SM00091

PAS domain

3 of 42

1.5

1.03

0.0052

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