node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AWC22_27565 | ORW56561.1 | AWC22_27565 | AWC22_06950 | DUF4440 domain-containing protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.876 |
AWC22_27565 | ORW63545.1 | AWC22_27565 | AWC22_00520 | DUF4440 domain-containing protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.877 |
AWC22_27565 | ORW67268.1 | AWC22_27565 | AWC22_27570 | DUF4440 domain-containing protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Amino acid permease; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.780 |
AWC22_27565 | ORW69242.1 | AWC22_27565 | AWC22_25745 | DUF4440 domain-containing protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.926 |
AWC22_27565 | ORW79735.1 | AWC22_27565 | AWC22_18500 | DUF4440 domain-containing protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.877 |
AWC22_27565 | glyA | AWC22_27565 | AWC22_06360 | DUF4440 domain-containing protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.882 |
AWC22_27565 | glyA-2 | AWC22_27565 | AWC22_20985 | DUF4440 domain-containing protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.882 |
AWC22_27565 | ilvA | AWC22_27565 | AWC22_25555 | DUF4440 domain-containing protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.934 |
AWC22_27565 | thrB | AWC22_27565 | AWC22_00530 | DUF4440 domain-containing protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.887 |
AWC22_27565 | trpA | AWC22_27565 | AWC22_25350 | DUF4440 domain-containing protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.864 |
ORW56561.1 | AWC22_27565 | AWC22_06950 | AWC22_27565 | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | DUF4440 domain-containing protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.876 |
ORW56561.1 | ORW63545.1 | AWC22_06950 | AWC22_00520 | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.896 |
ORW56561.1 | ORW69242.1 | AWC22_06950 | AWC22_25745 | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.924 |
ORW56561.1 | ORW79735.1 | AWC22_06950 | AWC22_18500 | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.986 |
ORW56561.1 | glyA | AWC22_06950 | AWC22_06360 | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.751 |
ORW56561.1 | glyA-2 | AWC22_06950 | AWC22_20985 | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.751 |
ORW56561.1 | ilvA | AWC22_06950 | AWC22_25555 | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.893 |
ORW56561.1 | thrB | AWC22_06950 | AWC22_00530 | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.876 |
ORW56561.1 | trpA | AWC22_06950 | AWC22_25350 | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.882 |
ORW63545.1 | AWC22_27565 | AWC22_00520 | AWC22_27565 | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | DUF4440 domain-containing protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.877 |