Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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[Homology]
Score
ENSPFOP00000001000Eukaryotic translation initiation factor 2-alpha kinase 3. (1104 aa)    
Predicted Functional Partners:
eif2s1
Eukaryotic translation initiation factor 2, subunit 1 alpha b.
   
 0.997
hspa5
Heat shock protein 5; Belongs to the heat shock protein 70 family.
    
 0.992
nfe2l2
Nuclear factor, erythroid 2-like 2a.
   
 0.975
EIF2AK3
Eukaryotic translation initiation factor 2 alpha kinase 3.
  
  
 
0.900
dnajc3
DnaJ (Hsp40) homolog, subfamily C, member 3a.
    
 0.846
atf6
Activating transcription factor 6.
    
 0.845
rpn2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]
    
   0.838
eif2a
Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
   
 
 0.816
LOC103137566
DnaJ (Hsp40) homolog, subfamily C, member 3b.
    
 0.813
dhx9
DRBM domain-containing protein.
   
 0.798
Your Current Organism:
Poecilia formosa
NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa
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