Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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tp63Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (667 aa)    
Predicted Functional Partners:
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.957
mdm2
MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.
    
 0.932
mdm4
MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.
    
 0.917
ENSPFOP00000014180
E3 ubiquitin-protein ligase.
    
 0.908
itch
E3 ubiquitin-protein ligase.
    
 0.908
ENSPFOP00000002566
Yes-associated protein 1.
    
 0.900
ENSPFOP00000009309
Uncharacterized protein.
    
 0.900
ENSPFOP00000006168
ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.898
chek2
Checkpoint kinase 2.
    
 0.885
chek1
Checkpoint kinase 1; Belongs to the protein kinase superfamily.
    
 0.867
Your Current Organism:
Poecilia formosa
NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa
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