Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ENSPFOP00000001322Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1446 aa)    
Predicted Functional Partners:
sirt1
Sirtuin 1.
    
 
 0.931
ENSPFOP00000001631
SET domain containing 2, histone lysine methyltransferase.
   
 
 0.926
tfb2m
rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
      
 0.901
med8
Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
      
 0.901
capn15
Calpain 15; Belongs to the peptidase C2 family.
      
 0.885
ENSPFOP00000013714
SET domain containing 1A, histone lysine methyltransferase.
   
 
 0.884
ENSPFOP00000016997
RRM domain-containing protein.
   
 
 0.884
setd1b
SET domain containing 1B, histone lysine methyltransferase a.
   
 
 0.884
mllt10
MLLT10 histone lysine methyltransferase DOT1L cofactor.
    
 
 0.876
LOC103148503
MLLT6, PHD finger containing.
    
 
 0.876
Your Current Organism:
Poecilia formosa
NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.