Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dyrk2Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2. (590 aa)    
Predicted Functional Partners:
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.851
ENSPFOP00000006168
ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.815
ENSPFOP00000013330
Ubiquitin protein ligase E3 component n-recognin 5.
   
 
 0.775
ENSPFOP00000003124
Damage-specific DNA binding protein 1.
    
 
 0.770
ENSPFOP00000001917
LisH domain-containing protein.
    
 
 0.764
DCAF1
DDB1 and CUL4 associated factor 1.
    
 
 0.764
ENSPFOP00000017914
Uncharacterized protein.
    
 
 0.764
DCAF7
DDB1 and CUL4 associated factor 7.
   
 
 0.747
LOC103134725
Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
    
 
 0.737
mdm2
MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.
    
 0.716
Your Current Organism:
Poecilia formosa
NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa
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